Ladinin 1

This article is about the gene. For the disease, see Leukocyte adhesion deficiency-1.

Ladinin-1 is a protein that in humans is encoded by the LAD1 gene.^[5][6][7]

LAD1
Identifiers
Aliases	LAD1, LadA, ladinin 1
External IDs	OMIM: 602314; MGI: 109343; HomoloGene: 4059; GeneCards: LAD1; OMA:LAD1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 201,380,833 bp[1] End 201,399,915 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E4 Start 135,746,336 bp[2] End 135,761,080 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen skin of leg mucosa of transverse colon gallbladder mucosa of ileum gums gingival epithelium rectum epithelium of colon mucosa of pharynx Top expressed in esophagus lip ileum transitional epithelium of urinary bladder epithelium of stomach large intestine left colon duodenum skin of abdomen crypt of lieberkuhn of small intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cadherin binding structural molecule activity Cellular component extracellular exosome extracellular region basement membrane actin cytoskeleton Biological process cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3898 16763 Ensembl ENSG00000159166 ENSMUSG00000041782 UniProt O00515 P57016 RefSeq (mRNA) NM_005558 NM_133664 RefSeq (protein) NP_005549 NP_598425 Location (UCSC) Chr 1: 201.38 – 201.4 Mb Chr 1: 135.75 – 135.76 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene may be an anchoring filament that is a component of basement membranes. It may contribute to the stability of the association of the epithelial layers with the underlying mesenchyme.^[7]