Laminin, beta 3

Laminin subunit beta-3 is a protein that in humans is encoded by the LAMB3 gene.^[5][6][7]

LAMB3
Identifiers
Aliases	LAMB3, BM600-125KDA, LAM5, LAMNB1, AI1A, Laminin, beta 3, laminin subunit beta 3, JEB1B, JEB1A
External IDs	OMIM: 150310; MGI: 99915; HomoloGene: 191; GeneCards: LAMB3; OMA:LAMB3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.2 Start 209,614,870 bp[1] End 209,652,425 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H6|1 97.71 cM Start 192,890,007 bp[2] End 193,026,186 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue periodontal fiber gingival epithelium olfactory zone of nasal mucosa jejunal mucosa mucosa of transverse colon skin of leg mucosa of ileum skin of abdomen mucosa of esophagus Top expressed in molar epithelium of stomach left colon granulocyte corneal stroma transitional epithelium of urinary bladder lip left lung mucous cell of stomach lactiferous gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding structural molecule activity protein-containing complex binding extracellular matrix structural constituent Cellular component extracellular region basement membrane laminin-5 complex collagen-containing extracellular matrix laminin complex Biological process hemidesmosome assembly cell adhesion extracellular matrix organization endodermal cell differentiation brown fat cell differentiation epidermis development animal organ morphogenesis tissue development cell migration substrate adhesion-dependent cell spreading basement membrane assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3914 16780 Ensembl ENSG00000196878 ENSMUSG00000026639 UniProt Q13751 Q61087 RefSeq (mRNA) NM_000228 NM_001017402 NM_001127641 NM_001277928 NM_008484 RefSeq (protein) NP_000219 NP_001017402 NP_001121113 NP_001264857 NP_032510 Location (UCSC) Chr 1: 209.61 – 209.65 Mb Chr 1: 192.89 – 193.03 Mb PubMed search [3] [4]
Wikidata
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LAMB3 encodes the beta 3 subunit of laminin. Laminin is composed of three subunits (alpha, beta, and gamma), and refers to a family of basement membrane proteins. For example, LAMB3 serves as the beta chain in laminin-5. Mutations in LAMB3 have been identified as the cause of various types of epidermolysis bullosa. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.^[7]