Late endosomal/lysosomal adaptor, mapk and mtor activator 1

Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 is a protein that in humans is encoded by the LAMTOR1 gene. ^[5]

LAMTOR1
Identifiers
Aliases	LAMTOR1, C11orf59, PDRO, Ragulator1, p18, p27RF-Rho, late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
External IDs	OMIM: 613510; MGI: 1913758; HomoloGene: 9909; GeneCards: LAMTOR1; OMA:LAMTOR1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.4 Start 72,085,895 bp[1] End 72,103,297 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E2 Start 101,555,111 bp[2] End 101,575,882 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte mucosa of ileum granulocyte right adrenal cortex left adrenal gland left adrenal cortex stromal cell of endometrium right lobe of thyroid gland C1 segment left lobe of thyroid gland Top expressed in white adipose tissue quadriceps femoris muscle yolk sac lip granulocyte skeletal muscle tissue proximal tubule right kidney muscle of thigh heart More reference expression data BioGPS n/a
Gene ontology Molecular function guanyl-nucleotide exchange factor activity protein binding molecular adaptor activity GTPase binding Cellular component endosome late endosome membrane membrane Ragulator complex lysosomal membrane membrane raft lysosome extracellular exosome plasma membrane azurophil granule membrane specific granule membrane ficolin-1-rich granule membrane Biological process regulation of cholesterol import regulation of cholesterol efflux endosome organization lysosome localization cellular response to amino acid stimulus cholesterol homeostasis regulation of receptor recycling lysosome organization regulation of cholesterol esterification positive regulation of TOR signaling positive regulation of MAPK cascade neutrophil degranulation regulation of macroautophagy regulation of cell growth regulation of molecular function endosomal transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55004 66508 Ensembl ENSG00000149357 ENSMUSG00000030842 UniProt Q6IAA8 Q9CQ22 RefSeq (mRNA) NM_017907 NM_025605 RefSeq (protein) NP_060377 NP_079881 Location (UCSC) Chr 11: 72.09 – 72.1 Mb Chr 7: 101.56 – 101.58 Mb PubMed search [3] [4]
Wikidata
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