MAP2K1IP1

Mitogen-activated protein kinase scaffold protein 1 is a scaffold protein that in humans is encoded by the MAPKSP1 gene.^[5][6][7]

LAMTOR3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SKO, 2ZL1, 3CPT
Identifiers
Aliases	LAMTOR3, MAP2K1IP1, MAPBP, MAPKSP1, MP1, PRO0633, Ragulator3, late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
External IDs	OMIM: 603296; MGI: 1929467; HomoloGene: 10539; GeneCards: LAMTOR3; OMA:LAMTOR3 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q23 Start 99,878,336 bp[1] End 99,894,428 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 G3 Start 137,624,267 bp[2] End 137,634,661 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of sigmoid colon oocyte retinal pigment epithelium ventricular zone islet of Langerhans Achilles tendon secondary oocyte palpebral conjunctiva rectum ganglionic eminence Top expressed in fossa facial motor nucleus secondary oocyte condyle renal corpuscle medullary collecting duct trigeminal ganglion atrioventricular junction vestibular membrane of cochlear duct Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function guanyl-nucleotide exchange factor activity protein binding molecular adaptor activity kinase activator activity Cellular component endosome membrane late endosome membrane focal adhesion Ragulator complex lysosomal membrane endosome membrane extracellular exosome late endosome plasma membrane specific granule membrane tertiary granule membrane Biological process regulation of TOR signaling MAPK cascade cellular response to amino acid stimulus positive regulation of TOR signaling neutrophil degranulation regulation of macroautophagy Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8649 56692 Ensembl ENSG00000109270 ENSMUSG00000091512 UniProt Q9UHA4 O88653 RefSeq (mRNA) NM_001243736 NM_021970 NM_019920 RefSeq (protein) NP_001230665 NP_068805 NP_064304 Location (UCSC) Chr 4: 99.88 – 99.89 Mb Chr 3: 137.62 – 137.63 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene was identified as an interacting protein that binds specifically to MAP kinase kinase MAP2K1/MEK1 and to MAP kinase MAPK2/ERK1. This protein enhances the activation of MAPK2, and thus is thought to function as an adaptor to enhance the efficiency of the MAP kinase cascade.^[7]

Interactions

MAP2K1IP1 has been shown to interact with MAP2K1.^[5][8]