Latrophilin 3

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Latrophilin 3

Latrophilin 3 is a protein that in humans is encoded by the ADGRL3 gene.[5][6]

Quick Facts ADGRL3, Available structures ...
ADGRL3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesADGRL3, CIRL3, LEC3, CL3, LPHN3, adhesion G protein-coupled receptor L3
External IDsOMIM: 616417; MGI: 2441950; HomoloGene: 22878; GeneCards: ADGRL3; OMA:ADGRL3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 4: 61.2 – 62.08 MbChr 5: 81.02 – 81.83 Mb
PubMed search[3][4]
Wikidata
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Function

This gene encodes a member of the latrophilin subfamily of G protein-coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane.[6]

Clinical significance

A version of this gene has been linked to attention deficit hyperactivity disorder (ADHD).[7]

See also

References

Further reading

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