Leucine rich repeat containing 15

Leucine rich repeat containing 15 is a cell membrane-expressed protein. In humans it is encoded by the LRRC15 ^[5] gene.^[6] It is located on chromosome 3 at 3q29. It belongs to the LRR superfamily, which is involved in cell–cell and cell–ECM interactions.

LRRC15
Identifiers
Aliases	LRRC15, LIB, Leucine rich repeat containing 15
External IDs	MGI: 1921738; HomoloGene: 26080; GeneCards: LRRC15; OMA:LRRC15 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q29 Start 194,355,249 bp[1] End 194,369,743 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B2 Start 30,088,120 bp[2] End 30,102,074 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in periodontal fiber tendon of biceps brachii hair follicle decidua tibia skin of hip skin of thigh cartilage tissue skin of arm mucosa of paranasal sinus Top expressed in lip body of femur calvaria skin of abdomen hair follicle molar skin of back conjunctival fornix fossa morula More reference expression data BioGPS n/a
Gene ontology Molecular function fibronectin binding protein kinase inhibitor activity laminin binding collagen binding Cellular component cytoplasm integral component of membrane extracellular exosome membrane extracellular space extracellular matrix collagen-containing extracellular matrix Biological process negative regulation of protein kinase activity cytokine-mediated signaling pathway negative regulation of receptor signaling pathway via JAK-STAT positive regulation of cell migration negative regulation of protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 131578 74488 Ensembl ENSG00000172061 ENSMUSG00000052316 UniProt Q8TF66 Q80X72 RefSeq (mRNA) NM_130830 NM_001135057 NM_028973 RefSeq (protein) NP_001128529 NP_570843 NP_083249 Location (UCSC) Chr 3: 194.36 – 194.37 Mb Chr 16: 30.09 – 30.1 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Preliminary evidence indicates that expression may be related to the severity of COVID-19^[7] and that it is an inhibitory accessory factor for SARS-CoV-2 cell entry.^{[8][9][10][11]}

LRRC15 lacks obvious intracellular domains. LRRC15 displays a highly restricted expression pattern, but is expressed in areas that make up innate immune barriers such as the placenta, skin, activated fibroblasts in wounds, and lymphoid tissues such as the spleen.^{[citation needed]}

LRRC15 may play some role in innate immunity.

LRRC15 is aberrantly expressed in cancer. It is highly expressed in CAFs within the stroma of numerous solid tumors and directly expressed in mesenchymal tumors such as glioblastoma, sarcomas, and melanoma.^{[citation needed]}

See also

• Leucine-rich repeat
• ACE2