LY-266,097

LY-266,097 is a synthetic β-carboline which acts as a potent and selective antagonist for the 5-HT_2B receptor, with more than 100x selectivity over the related 5-HT_2A and 5-HT_2C receptor subtypes.^[1] However, other sources have stated that LY-266,097 is actually a biased agonist of the receptor, selective for G_q signaling but not β-arrestin2.^[2] The drug has been used to study the role of the 5-HT_2B receptor in modulating dopamine release in the brain,^[3][4] as well as its involvement in other processes such as allodynia.^[5]

LY-266,097

Legal status
Legal status	In general: uncontrolled
Identifiers
IUPAC name 1-[(2-chloro-3,4-dimethoxyphenyl)methyl]-6-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
CAS Number	208591-60-0 Y
PubChem CID	9953185
ChemSpider	8128795
UNII	2Z9TC7YMY4
ChEMBL	ChEMBL95121
Chemical and physical data
Formula	C21H23ClN2O2
Molar mass	370.88 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1=CC2=C(C=C1)NC3=C2CCNC3CC4=C(C(=C(C=C4)OC)OC)Cl
InChI InChI=1S/C21H23ClN2O2/c1-12-4-6-16-15(10-12)14-8-9-23-17(20(14)24-16)11-13-5-7-18(25-2)21(26-3)19(13)22/h4-7,10,17,23-24H,8-9,11H2,1-3H3 Key:NJLHHCITDFZZSE-UHFFFAOYSA-N

See also

• Substituted β-carboline