LY-404187

LY-404187 is an AMPA receptor positive allosteric modulator which was developed by Eli Lilly and Company.^[1] It is a member of the biarylpropylsulfonamide class of AMPA receptor potentiators.^[2]

LY-404187

Clinical data
Other names	LY-404,187; N-2-[4-(4-cyanophenyl)phenyl]propyl-2-propanesulfonamide
ATC code	none
Legal status
Legal status	US: Investigational New Drug
Identifiers
IUPAC name N-[2-(4'-cyanobiphenyl-4-yl)propyl]propane-2-sulfonamide
CAS Number	211311-95-4 Y
ChemSpider	18962921 N
UNII	75W6I8W6OU
CompTox Dashboard (EPA)	DTXSID00432983
Chemical and physical data
Formula	C19H22N2O2S
Molar mass	342.46 g·mol−1
3D model (JSmol)	Interactive image
SMILES N#Cc2ccc(cc2)-c1ccc(C(C)CNS(=O)(=O)C(C)C)cc1
InChI InChI=1S/C19H28N2O2S/c1-14(2)24(22,23)21-13-15(3)17-8-10-19(11-9-17)18-6-4-16(12-20)5-7-18/h4-7,14-15,17,19,21H,8-11,13H2,1-3H3 N Key:AIALBPYHYGYYRB-UHFFFAOYSA-N N
NY (what is this?)  (verify)

LY-404187 has been demonstrated to enhance cognitive function in animal studies, and has also shown effects suggesting antidepressant action as well as having possible application in the treatment of schizophrenia, Parkinson's disease and ADHD. These effects appear to be mediated through multiple mechanisms of action secondary to AMPA receptor potentiation, with a prominent effect seen in research being increased levels of BDNF in the brain.^[3] It may therefore be continued on to human trials, although Eli Lilly has developed a whole family of biarylpropylsulfonamide derivatives and it is unclear at this stage which compound is most likely to be selected for further development.^[4][5]

See also

• AMPA receptor positive allosteric modulator