Latent TGF-beta binding protein

The latent TGF-beta binding proteins (LTBP) are a family of carrier proteins.^[1][2]

LTBP is a family of secreted multidomain proteins that were originally identified by their association with the latent form of transforming growth factors. They interact with a variety of extracellular matrix proteins and may play a role in the regulation of TGF beta bioavailability.

Genes

latent transforming growth factor beta binding protein 1 Identifiers Symbol LTBP1 Alt. symbols TGF-beta1-BP-1 NCBI gene 4052 HGNC 6714 OMIM 150390 RefSeq NM_206943 UniProt Q14766 Other data Locus Chr. 2 p22-p21 Search for Structures Swiss-model Domains InterPro

latent transforming growth factor beta binding protein 2 Identifiers Symbol LTBP2 Alt. symbols LTBP3, C14orf141 NCBI gene 4053 HGNC 6715 OMIM 602091 RefSeq NM_000428 UniProt Q14767 Other data Locus Chr. 14 q24.3 Search for Structures Swiss-model Domains InterPro

latent transforming growth factor beta binding protein 3 Identifiers Symbol LTBP3 Alt. symbols LTBP2 NCBI gene 4054 HGNC 6716 OMIM 602090 RefSeq NM_021070 UniProt Q9NS15 Other data Locus Chr. 11 q12 Search for Structures Swiss-model Domains InterPro

latent transforming growth factor beta binding protein 4 Identifiers Symbol LTBP4 Alt. symbols LTBP-4, LTBP-4L NCBI gene 8425 HGNC 6717 OMIM 604710 RefSeq NM_003573 UniProt Q8N2S1 Other data Locus Chr. 19 q13.1-13.2 Search for Structures Swiss-model Domains InterPro