Limulus clotting enzyme

Limulus clotting enzyme (EC 3.4.21.86, clotting enzyme) is an enzyme.^[1][2] This enzyme catalyses the following chemical reaction:

Selective cleavage of -Arg¹⁸- and -Arg⁴⁷- bonds in coagulogen to form coagulin and fragments

Limulus clotting enzyme
Identifiers
EC no.	3.4.21.86
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

This enzyme is present in the hemocyte granules of horseshoe crabs Limulus and Tachypleus. In the immunity-related clotting pathways of these organisms, it is the final enzyme responsible for the activation of coagulin.^[3]