List of Schedule IV controlled substances (U.S.)

This is the list of Schedule IV controlled substances in the United States as defined by the Controlled Substances Act.^[1] The following findings are required for substances to be placed in this schedule:^[2]

1. The drug or other substance has a low potential for abuse relative to the drugs or other substances in schedule III.
2. The drug or other substance has a currently accepted medical use in treatment in the United States.
3. Abuse of the drug or other substance may lead to limited physical dependence or psychological dependence relative to the drugs or other substances in schedule III.

The complete list of Schedule IV substances is as follows. The Administrative Controlled Substances Code Number and Federal Register citation for each substance is included.

Narcotics

ACSCN	Drug
9167	Not more than 1 milligram of difenoxin and not less than 25 micrograms of atropine sulfate per dosage unit.[3]
9278	Dextropropoxyphene[4]
9752	Tramadol[5]

Depressants

ACSCN	Drug
2731	Alfaxalone[6]
2882	Alprazolam[7]
2145	Barbital[8][note 1]
2400	Brexanolone[9]
2748	Bromazepam[10]
2749	Camazepam[10]
8192	Carisoprodol[11]
2460	Chloral betaine[8][note 1]
2465	Chloral hydrate[8][note 1]
2744	Chlordiazepoxide[12]
2751	Clobazam[10]
2737	Clonazepam[12]
2768	Clorazepate[12]
2752	Clotiazepam[10]
2753	Cloxazolam[10]
2410	Daridorexant[13]
2754	Delorazepam[10]
2765	Diazepam[12]
2467	Dichloraphenazone[14]
2756	Estazolam[10]
2540	Ethchlorvynol[8][note 1]
2545	Ethinamate[8][note 1]
2758	Ethyl loflazepate[10]
2759	Fludiazepam[10]
2763	Flunitrazepam† [10]
2767	Flurazepam[12]
2138	Fospropofol[15]
2762	Halazepam[16]
2771	Haloxazolam[10]
2772	Ketazolam[10]
2245	Lemborexant[17]
2773	Loprazolam[10]
2885	Lorazepam[18]
2774	Lormetazepam[10]
2800	Mebutamate[19]
2836	Medazepam[10]
2820	Meprobamate[8][note 1]
2264	Methohexital[8][note 1]
2250	Methylphenobarbital (mephobarbital)[8][note 1]
2884	Midazolam[20]
2837	Nimetazepam[10]
2834	Nitrazepam[10]
2838	Nordiazepam[10]
2835	Oxazepam[12]
2839	Oxazolam[10]
2585	Paraldehyde[8][note 1]
2591	Petrichloral[8][note 1]
2285	Phenobarbital[8][note 1]
2883	Pinazepam[10]
2764	Prazepam[21]
2881	Quazepam[20]
2846	Remimazolam[22]
2223	Suvorexant[23]
2925	Temazepam†[24]
2886	Tetrazepam[10]
2887	Triazolam[25]
2781	Zaleplon[26]
2783	Zolpidem[27]
2784	Zopiclone[28]
2420	Zuranolone[29]

^†Flunitrazepam has not been approved by the Food and Drug Administration for medical use, and is considered to be an illegal drug.

^†Temazepam may require a specially coded prescription in certain States.

Lorcaserin

ACSCN	Drug
1625	Lorcaserin[30]

Stimulants

ACSCN	Drug
1230	Cathine[31]
1610	Diethylpropion[32]
1760	Fencamfamin[31]
1575	Fenproporex[31]
1605	Mazindol[33]
1580	Mefenorex[31]
1680	Modafinil and enantiopure armodafinil[34]
1530	Pemoline[35]
1640	Phentermine[32]
1750	Pipradrol[36]
1729	Serdexmethylphenidate[37]
1675	Sibutramine[38]
1650	Solriamfetol[39]
1635	SPA / (-)-1-dimethylamino- 1,2-diphenylethane[36]

Others

ACSCN	Drug
9709	Pentazocine[40]
9720	Butorphanol[41]
9725	Eluxadoline[42]

See also

• List of Schedule I controlled substances (U.S.)
• List of Schedule II controlled substances (U.S.)
• List of Schedule III controlled substances (U.S.)
• List of Schedule V controlled substances (U.S.)

Notes

1. This substance was expressly scheduled by the Controlled Substances Act on October 27, 1970. The 1974 Federal Register ruling (by Administrator John R. Bartels, Jr.) merely organized its listing in the Code of Federal Regulations.