Fludiazepam

Fludiazepam
Clinical data
Trade names	Erispan (JP, TW)
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral (tablets)
Drug class	Benzodiazepine
ATC code	N05BA17 (WHO) ;
Legal status
Legal status	BR: Class B1 (Psychoactive drugs); CA: Schedule IV; DE: Anlage III (Special prescription form required); US: Schedule IV;
Pharmacokinetic data
Metabolism	Hepatic
Excretion	Renal
Identifiers
	IUPAC name 7-chloro-5-(2-fluorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one;
CAS Number	3900-31-0 ;
PubChem CID	3369;
DrugBank	DB01567 ;
ChemSpider	3252 ;
UNII	7F64A2K16Z;
KEGG	D01354 ;
ChEBI	CHEBI:31618 ;
ChEMBL	ChEMBL13291 ;
CompTox Dashboard (EPA)	DTXSID00192277 ;
ECHA InfoCard	100.292.343
Chemical and physical data
Formula	C16H12ClFN2O
Molar mass	302.73 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C1CN=C(C2=CC=CC=C2F)C3=CC(Cl)=CC=C3N1C;
	InChI InChI=1S/C16H12ClFN2O/c1-20-14-7-6-10(17)8-12(14)16(19-9-15(20)21)11-4-2-3-5-13(11)18/h2-8H,9H2,1H3 ; Key:ROYOYTLGDLIGBX-UHFFFAOYSA-N ;
	(verify)

Fludiazepam,^[2] marketed under the brand name Erispan (エリスパン)^[3]^[4] is a potent benzodiazepine and 2ʹ-fluoro derivative of diazepam,^[5] originally developed by Hoffmann-La Roche in the 1960s.^[6] It is marketed in Japan and Taiwan. ^{[citation needed]} It exerts its pharmacological properties via enhancement of GABAergic inhibition.^[7] Fludiazepam has 4 times more binding affinity for benzodiazepine receptors than diazepam.^[8] It possesses anxiolytic,^[9]^[10]^[11] anticonvulsant, sedative, hypnotic and skeletal muscle relaxant properties.^[12] Fludiazepam has been used recreationally.^[13]

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