List of adverse effects of aripiprazole

The rates of adverse effects of aripiprazole are:^{[1][2][3][4][5]}

Adults

Very common (>10% incidence)

• Weight gain
• Headache
• Agitation
• Insomnia
• Anxiety
• Nausea & vomiting
• Akathisia — a sense of unease and restlessness that presents itself with anxiety
• Lightheadedness
• Constipation
• Emotional instability
• Euphoria or Dysphoria

Common (1–10% incidence)

• Dizziness
• Dyspepsia — indigestion
• Somnolence — which is usually mild and transient and less severe than that seen with most antipsychotics.^[6]
• Fatigue
• Restlessness
• Dry mouth
• Extrapyramidal side effects (e.g. dystonia, parkinsonism, tremor, myoclonic jerks, etc.)
• Orthostatic hypotension
• Musculoskeletal stiffness
• Abdominal discomfort
• Blurred vision
• Cough
• Pain
• Myalgia
• Rash
• Rhinitis

Uncommon (0.1–1% incidence)

• Leukopenia
• Thrombocytopenia
• Bradycardia (low heart rate)
• Palpitations
• Orthostatic hypotension
• Dry eye
• Photophobia
• Diplopia
• Eyelid oedema
• Photopsia
• Diarrhoea
• Gastritis
• Pathological gambling^[7]
• Dysphagia
• Gastroesophageal reflux disease
• Swollen tongue
• Oesophagitis
• Hypoaesthesia oral
• Face oedema
• Gait disturbance
• Chills
• Discomfort
• Feeling abnormal
• Mobility decreased
• Self-mutilation
• Heart rate increased
• Blood glucose increased
• Pyrexia
• Blood prolactin increased
• Blood urea increased
• Electrocardiogram QT prolonged
• Blood bilirubin increased
• Hepatic enzyme increased
• Increased appetite
• Nocturia
• Polyuria
• Pollakiuria
• Incontinence
• Urinary retention
• Sexual dysfunction
• Amenorrhoea
• Pruritus
• Photosensitivity reaction
• Urticaria

Rare (<0.1%)

• Neuroleptic malignant syndrome (Combination of fever, muscle stiffness, faster breathing, sweating, reduced consciousness, and sudden change in blood pressure and heart rate)
• Neutropenia^[8]
• Suicidal ideation and behavior
• Depression
• Painful and/or sustained erection (Priapism)
• Seizures^[9]
• Rhabdomyolysis
• Agranulocytosis
• Cardiopulmonary failure
• Myocardial infarction (heart attack)
• Atrial flutter
• Supraventricular tachycardia
• Ventricular tachycardia
• Atrioventricular block
• Extrasystoles
• Sinus tachycardia
• Atrial fibrillation
• Angina pectoris
• Myocardial ischaemia
• Pancreatitis
• Diabetic ketoacidosis
• Prolonged QT interval (less common than with most other atypical antipsychotic drugs)^[6]
• Speech disorder
• Electrolyte abnormalities including hyponatraemia, hypokalaemia, hypocalcaemia, etc.
• Hypertension
• Dysphagia
• Oropharyngeal spasm
• Laryngospasm
• Hepatitis
• Jaundice
• Hypersalivation
• Chest pain
• Urinary retention or incontinence
• Alopecia (hair loss)
• Photosensitivity reaction
• Rash
• Xerostomia (when given by injection)
• Tardive dyskinesia (As with all antipsychotic medication, patients using aripiprazole may develop the permanent neurological disorder tardive dyskinesia.)^[10][11][12]
• Stroke
• Transient Ischaemic Attack
• Increased body temperature
• Angioedema
• Cardiorespiratory arrest
• Cardiorespiratory failure

Sudden unexplained death has been reported, however the frequency is unknown.^[13]

Common in children

• Feeling sleepy
• Headache
• Vomiting
• Fatigue
• Increased appetite
• Insomnia
• Nausea
• Stuffy nose
• Weight gain
• Uncontrolled movement such as restlessness, tremor muscle stiffness^[7]