| Rank | Institution | Location | Degree(s) granted | Students | % out of state | Founded |
| 1 | University of Pittsburgh | Pittsburgh | BA, BS, BASW, BSE, BSN, BPhil, MA, MS, MLIS, MBA, JD, MD, PharmD, EdD, PhD | 29,178 | 43% | 1787 |
| 2 | Community College of Allegheny County | Pittsburgh | Assoc. | 18,913 | 2% | 1966 |
| 3 | Carnegie Mellon University | Pittsburgh | BA, BS, BFA, BSA, BCSA, MA, MS, MET, MHCI, MBA, PhD | 14,799 | 82% | 1900 |
| 4 | Indiana University of Pennsylvania | Indiana | BA, BS, MBA, PhD | 11,325 | 7% | 1875 |
| 5 | Duquesne University | Pittsburgh | BA, BM, BS, MA, MM, MS, MBA, JD, PsyD, PhD | 10,364 | 25% | 1878 |
| 6 | Pennsylvania Western University, California | California | BA, BS, MA, MS, PhD | 8,608 | 10% | 1852 |
| 7 | Slippery Rock University of Pennsylvania | Slippery Rock | BA, BS, BFA, BSBA, BSEd, BSN, BM, MA, MS, MSW, MEd, MMT, MPH, MBA, PhD, EdD, DPT, DOT | 8,559 | 11% | 1889 |
| 8 | Westmoreland Community College | Youngwood | Assoc. | 7,202 | | 1970 |
| 9 | Robert Morris University | Moon Township | BA, BFA, BS, BSBA, BSN, MBA, MEd, MS, MSN, NP, PhD[1] | 5,181 | 16% | 1921 |
| 10 | Point Park University | Pittsburgh | PhD, MBA | 3,827 | 21% | 1960 |
| 11 | Butler Community College | Butler Township | Assoc. | 3,813 | 1% | 1965 |
| 12 | Franciscan University | Steubenville, Ohio | BA, BS, MBA | 2,731 | | 1946 |
| 13 | Beaver Community College | Center Township | Assoc. | 2,576 | 5% | 1966 |
| 14 | Eastern Gateway Community College | Steubenville, Ohio | Assoc. | 2,532 | | 1966 |
| 15 | West Liberty University | West Liberty, West Virginia | BA MA | 2,530 | | 1837 |
| 16 | Seton Hill University | Greensburg | BA MA | 2,500 | | 1885 |
| 17 | Grove City College | Grove City | BA, BS | 2,373 | 53% | 1876 |
| 18 | Chatham University | Pittsburgh | BA MA | 2,300 | | 1869 |
| 19 | Pittsburgh Technical College | Oakdale | BA, BS | 2,000 | | 1946 |
| 20 | St. Vincent College | Latrobe | BA | 1,929 | | 1846 |
| 21 | Carlow University | Pittsburgh | BA MA | 1,897 | | 1929 |
| 22 | Geneva College | Beaver Falls | BA | 1,879 | | 1848 |
| 23 | University of Pittsburgh at Greensburg | Hempfield | BA | 1,325 | 12% | 1963 |
| 24 | La Roche University | McCandless | BA | 1,707 | | 1963 |
| 25 | Washington & Jefferson College | Washington | BA | 1,519 | | 1781 |
| 26 | Westminster College | New Wilmington | BA M.Ed. | 1,550 | | 1852 |
| 27 |
Waynesburg University |
Waynesburg |
BA MA MS MBA PhD |
1,322 |
|
1849 |
| 28 | PSU Fayette | Lemont Furnace | BA | 1,119 | | 1965 |
| 29 | Bethany College | Bethany, West Virginia | BA | 1,030 | | 1840 |
| 30 | PSU Beaver | Center Township | BA | 759 | 8% | 1965 |
| 31 | PSU Allegheny | McKeesport | BA | 635 | 9% | 1934 |
| 32 | PSU New Kensington | New Kensington | BA | 715 | 2% | 1958 |
| 33 | UPMC Shadyside School of Nursing | Pittsburgh | RN | 488 | | 1884 |
| 34 | Pittsburgh Institute of Aeronautics | West Mifflin | Assoc. | 285 | | 1929 |
| 35 | Trinity School for Ministry | Ambridge | BA | 150 | | 1975 |
| 36 | IUP (Northpointe) | Freeport | BA | | | 2004 |
| 37 | Waynesburg University (Southpointe) | Canonsburg | BA | | | 2001 |
| 38 | LECOM at Seton Hill | Greensburg | DO | | | 1992 |
| 39 | Pittsburgh Theological Seminary | Pittsburgh | M.Div, M.T.S., D.Min | | | 1794 |
| 40 | West Penn Hospital School of Nursing | Pittsburgh | RN | | | 1892 |
| 41 | Reformed Presbyterian Seminary | Pittsburgh | M.Div, M.T.S., D.Min | | | 1810 |
| 42 | Byzantine Catholic Seminary | Pittsburgh | BA | | | 1950 |
| 43 | Bidwell Training Center | Pittsburgh | Assoc., Diplomas | approx. 200 | | 1968 |
| 44 | Art Institute of Pittsburgh | Pittsburgh | BA, BS, Assoc., Diplomas | CLOSED | | 1921 [2] |