| Language | Speakers | Status | Comments | Ref | 
|---|
| Acatepec Mazatec language, Acatepec Mazatec[1] |  | Vulnerable |  |  | 
| Akatek language, Akatek[1] |  | Vulnerable |  |  | 
| Awakatek language, Awakatek[1] |  | Critically endangered |  |  | 
| Ayapanec language, Ayapanec[1] |  | Critically endangered |  |  | 
| Ayapenaco language, Ayapenaco[1] |  | Critically endangered |  |  | 
| Ayautla Mazatec language, Ayautla Mazatec[1] |  | Vulnerable |  |  | 
| Central Cuicatec language, Central Cuicatec[1] |  | Vulnerable |  |  | 
| Central Náhuatl language, Central Náhuatl[1] |  | Vulnerable |  |  | 
| Central Otomí language, Central Otomí[1] |  | Definitely endangered |  |  | 
| Central Pame language, Central Pame[1] |  | Vulnerable |  |  | 
| Central Popoloc language, Central Popoloc[1] |  | Severely endangered |  |  | 
| Central Tlapanec language, Central Tlapanec[1] |  | Vulnerable |  |  | 
| Central Zoque language, Central Zoque[1] |  | Definitely endangered |  |  | 
| Chatino of the western lowlands[1] |  | Definitely endangered |  |  | 
| Chatino of Zacatepec language, Chatino of Zacatepec[1] |  | Definitely endangered |  |  | 
| Chichimec language, Chichimec[1] |  | Vulnerable |  |  | 
| Chihuahua Lower Pima language, Chihuahua Lower Pima[1] |  | Definitely endangered |  |  | 
| Chilchotla Mazatec language, Chilchotla Mazatec[1] |  | Vulnerable |  |  | 
| Chiquihuitlán Mazatec language, Chiquihuitlán Mazatec[1] |  | Definitely endangered |  |  | 
| Chontal Tabasco language, Chontal Tabasco[1] |  | Severely endangered |  |  | 
| Chuj language, Chuj[1] |  | Critically endangered |  |  | 
| Cocopa language, Cocopa[1] |  | Definitely endangered |  |  | 
| Eastern Chocho language, Eastern Chocho[1] |  | Severely endangered |  |  | 
| Eastern Cuicatec language, Eastern Cuicatec[1] |  | Vulnerable |  |  | 
| Eastern Mazahua language, Eastern Mazahua[1] |  | Definitely endangered |  |  | 
| Eastern Popoloc language, Eastern Popoloc[1] |  | Vulnerable |  |  | 
| Eastern Tlapanec language, Eastern Tlapanec[1] |  | Vulnerable |  |  | 
| Eloxochitlán Mazatec language, Eloxochitlán Mazatec[1] |  | Vulnerable |  |  | 
| Filomeno Mata Totonac language, Filomeno Mata Totonac[1] |  | Vulnerable |  |  | 
| Higher Reservoir Mazatec language, Higher Reservoir Mazatec[1] |  | Vulnerable |  |  | 
| Highland Chontal language, Highland Chontal[1] |  | Severely endangered |  |  | 
| Highland Mazatec language, Highland Mazatec[1] |  | Vulnerable |  |  | 
| Huasteca Náhuatl language, Huasteca Náhuatl[1] |  | Vulnerable |  |  | 
| Huehuetla Tepehua language, Huehuetla Tepehua[1] |  | Definitely endangered |  |  | 
| Huehuetlán Mazatec language, Huehuetlán Mazatec[1] |  | Vulnerable |  |  | 
| Huichol language, Huichol[1] |  | Vulnerable |  |  | 
| Isthmus Náhuatl language, Isthmus Náhuatl[1] |  | Vulnerable |  |  | 
| Ixcatec language, Ixcatec[1] |  | Critically endangered |  |  | 
| Ixcatlán Mazatec language, Ixcatlán Mazatec[1] |  | Vulnerable |  |  | 
| Ixil language, Ixil[1] |  | Critically endangered |  |  | 
| Ixtenco Otomí language, Ixtenco Otomí[1] |  | Severely endangered |  |  | 
| Jakaltek language, Jakaltek[1] |  | Severely endangered |  |  | 
| Kʼicheʼ language, Kʼicheʼ[1] |  | Definitely endangered |  |  | 
| Kaqchikel language, Kaqchikel[1] |  | Critically endangered |  |  | 
| Kickapoo language, Kickapoo[1] |  | Critically endangered |  |  | 
| Kiliwa language, Kiliwa[1] |  | Critically endangered |  |  | 
| Lacandón language, Lacandón[1] |  | Critically endangered |  |  | 
| Lower Mixe language, Lower Mixe[1] |  | Vulnerable |  |  | 
| Lower Northwestern Otomí language, Lower Northwestern Otomí[1] |  | Vulnerable |  |  | 
| Lowland Chontal language, Lowland Chontal[1] |  | Critically endangered |  |  | 
| Lowland Mazatec language, Lowland Mazatec[1] |  | Vulnerable |  |  | 
| Malinaltepec Tlapanec language, Malinaltepec Tlapanec[1] |  | Vulnerable |  |  | 
| Mam language, Mam[1] |  | Severely endangered |  |  | 
| Matlatzinca language, Matlatzinca[1] |  | Definitely endangered |  |  | 
| Mayo language, Mayo[1] |  | Critically endangered |  |  | 
| Mazatlán Mazatec language, Mazatlán Mazatec[1] |  | Vulnerable |  |  | 
| Mezquital Otomí language, Mezquital Otomí[1] |  | Definitely endangered |  |  | 
| Misantla Totonac language, Misantla Totonac[1] |  | Critically endangered |  |  | 
| Mixtec of San Miguel Piedras language, Mixtec of San Miguel Piedras[1] |  | Severely endangered |  |  | 
| Mixtec of San Pedro Tidaá language, Mixtec of San Pedro Tidaá[1] |  | Severely endangered |  |  | 
| Mixtec of Santa Cruz Itundujia language, Mixtec of Santa Cruz Itundujia[1] |  | Definitely endangered |  |  | 
| Mixtec of Santa Inés de Zaragoza language, Mixtec of Santa Inés de Zaragoza[1] |  | Definitely endangered |  |  | 
| Mixtec of the central Ravine[1] |  | Definitely endangered |  |  | 
| Mixtec of the northeast lowlands[1] |  | Severely endangered |  |  | 
| Mixtec of the Puebla-Oaxaca border[1] (several Mixtec languages go by this name; UNESCO intends Chazumba Mixtec)
 |  | Definitely endangered |  |  | 
| Mixtec of the southwest of Puebla[1] |  | Definitely endangered |  |  | 
| Mixtec of Tlaltempan language, Mixtec of Tlaltempan[1] |  | Definitely endangered |  |  | 
| Mixtec of Villa de Tututepec language, Mixtec of Villa de Tututepec[1] |  | Definitely endangered |  |  | 
| Mixtec of Zapotitlán language, Mixtec of Zapotitlán[1] |  | Severely endangered |  |  | 
| Motocintlec language, Motocintlec[1] |  | Critically endangered |  |  | 
| Mountain Guarijío language, Mountain Guarijío[1] |  | Vulnerable |  |  | 
| Northern Cuicatec language, Northern Cuicatec[1] |  | Vulnerable |  |  | 
| Northern Pame language, Northern Pame[1] |  | Definitely endangered |  |  | 
| Northern Popoloc language, Northern Popoloc[1] |  | Vulnerable |  |  | 
| Northern Tepehuán language, Northern Tepehuán[1] |  | Definitely endangered |  |  | 
| Northern Tlapanec language, Northern Tlapanec[1] |  | Vulnerable |  |  | 
| Northern Totonac language, Northern Totonac[1] |  | Critically endangered |  |  | 
| Northwestern Otomí language, Northwestern Otomí[1] |  | Vulnerable |  |  | 
| Northwestern Tarahumara language, Northwestern Tarahumara[1] |  | Vulnerable |  |  | 
| Northwestern Tlapanec language, Northwestern Tlapanec[1] |  | Vulnerable |  |  | 
| Oʼodham language, Oʼodham[1] |  | Definitely endangered |  |  | 
| Ocopetatillo Mazatec language, Ocopetatillo Mazatec[1] |  | Vulnerable |  |  | 
| Ocoyoacac Otomí language, Ocoyoacac Otomí[1] |  | Severely endangered |  |  | 
| Olultecan language, Olultecan [typo][1] |  | Severely endangered |  |  | 
| Ozumatlán Totonac language, Ozomatlán Totonac[1] |  | Critically endangered |  |  | 
| Paipai language, Paipai[1] |  | Severely endangered |  |  | 
| Papantla Totonac language, Papantla Totonac[1] |  | Definitely endangered |  |  | 
| Patla-Chicontla Totonac language, Patla-Chicontla Totonac[1] |  | Severely endangered |  |  | 
| Purépecha language, Purépecha[1] |  | Vulnerable |  |  | 
| Pisaflores Tepehua language, Pisaflores Tepehua[1] |  | Vulnerable |  |  | 
| Puebla Mazatec language, Puebla Mazatec[1] |  | Vulnerable |  |  | 
| River Guarijío language, River Guarijío[1] |  | Vulnerable |  |  | 
| San Dionisio del Mar Huave language, San Dionisio del Mar Huave[1] |  | Definitely endangered |  |  | 
| San Francisco del Mar Huave language, San Francisco del Mar Huave[1] |  | Critically endangered |  |  | 
| San Mateo del Mar Huave language, San Mateo del Mar Huave[1] |  | Vulnerable |  |  | 
| Santa María del Mar Huave language, Santa María del Mar Huave[1] |  | Severely endangered |  |  | 
| Sayultec language, Sayultec[1] |  | Definitely endangered |  |  | 
| Seri language, Seri[1] |  | Vulnerable |  |  | 
| Sierra de Puebla Nahuatl language, Sierra de Puebla Náhuatl[1] |  | Definitely endangered |  |  | 
| Sierra Otomí language, Sierra Otomí[1] |  | Vulnerable |  |  | 
| Sierra Popoluca language, Sierra Popoluca[1] |  | Vulnerable |  |  | 
| Sierra Totonac language, Sierra Totonac[1] |  | Severely endangered |  |  | 
| Sonora Lower Pima language, Sonora Lower Pima[1] |  | Severely endangered |  |  | 
| Southeastern Tarahumara language, Southeastern Tarahumara[1] |  | Vulnerable |  |  | 
| Southern Chocho language, Southern Chocho[1] |  | Severely endangered |  |  | 
| Southern Tlapanec language, Southern Tlapanec[1] |  | Severely endangered |  |  | 
| Southern Zoque language, Southern Zoque[1] |  | Definitely endangered |  |  | 
| Southwestern Tepehuan language, Southwestern Tepehuan[1] |  | Vulnerable |  |  | 
| Southwestern Tlapanec language, Southwestern Tlapanec[1] |  | Vulnerable |  |  | 
| Soyaltepec Mazatec language, Soyaltepec Mazatec[1] |  | Vulnerable |  |  | 
| Tabasco Náhuatl language, Tabasco Náhuatl[1] |  | Critically endangered |  |  | 
| Tecóatl Mazatec language, Tecóatl Mazatec[1] |  | Vulnerable |  |  | 
| Teko language, Teko[1] |  | Severely endangered |  |  | 
| Texistepecan language, Texistepecan[1] |  | Severely endangered |  |  | 
| Tilapa Otomí language, Tilapa Otomí[1] |  | Severely endangered |  |  | 
| Tipai language, Tipai[1] |  | Severely endangered |  |  | 
| Tlachichilco Tepehua language, Tlachichilco Tepehua[1] |  | Definitely endangered |  |  | 
| Tlahuica language, Tlahuica[1] |  | Severely endangered |  |  | 
| Tuzantec language, Tuzantec[1] |  | Critically endangered |  |  | 
| Valle Nacional Chinantec language, Valle Nacional Chinantec[1] |  | Definitely endangered |  |  | 
| Western Chocho language, Western Chocho[1] |  | Severely endangered |  |  | 
| Western Mazahua language, Western Mazahua[1] |  | Definitely endangered |  |  | 
| Western Mazatec language, Western Mazatec[1] |  | Vulnerable |  |  | 
| Western Náhuatl language, Western Náhuatl[1] |  | Severely endangered |  |  | 
| Western Otomí language, Western Otomí[1] |  | Severely endangered |  |  | 
| Western Popoloc language, Western Popoloc[1] |  | Severely endangered |  |  | 
| Western Tarahumara language, Western Tarahumara[1] |  | Vulnerable |  |  | 
| Western Tlapanec language, Western Tlapanec[1] |  | Vulnerable |  |  | 
| Western Zoque language, Western Zoque[1] |  | Vulnerable |  |  | 
| Yaqui language, Yaqui[1] |  | Vulnerable |  |  | 
| Zapotec of Asunción Tlacolulita language, Zapotec of Asunción Tlacolulita[1] |  | Critically endangered |  |  | 
| Zapotec of Mixtepe language, Zapotec of Mixtepe[1] |  | Critically endangered |  |  | 
| Zapotec of Petapa language, Zapotec of Petapa[1] |  | Definitely endangered |  |  | 
| Zapotec of San Antonino el Alto language, Zapotec of San Antonino el Alto[1] |  | Definitely endangered |  |  | 
| Zapotec of San Bartolo Yautepec language, Zapotec of San Bartolo Yautepec[1] |  | Severely endangered |  |  | 
| Zapotec of San Felipe Tejalapan language, Zapotec of San Felipe Tejalapan[1] |  | Critically endangered |  |  | 
| eastern lowlands Zapotec of the Southern mountains[1] |  | Definitely endangered |  |  | 
| northeast Zapotec of the Southern mountains[1] |  | Definitely endangered |  |  | 
| northwest lowlands Zapotec of the Southern mountains[1] |  | Definitely endangered |  |  | 
| north Zapotec of the Valleys[1] |  | Severely endangered |  |  | 
| central Zapotec of the Valleys[1] |  | Severely endangered |  |  | 
| middle northwest Zapotec of the Valleys[1] |  | Definitely endangered |  |  | 
| west Zapotec of the Valleys[1] |  | Definitely endangered |  |  | 
| Zapotec of Zimatlán de Álvarez language, Zapotec of Zimatlán de Álvarez[1] |  | Definitely endangered |  |  | 
|