List of investigational sleep drugs

This is a dynamic list and may never be able to satisfy particular standards for completeness. You can help by adding missing items with reliable sources.

This is a list of investigational sleep drugs, or drugs for the treatment of sleep disorders that are currently under development for clinical use but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.

This list was last comprehensively updated sometime between June 2017 and August 2021. It is likely to become outdated with time.

Insomnia

GABA_A receptor potentiators

• Lorediplon (GF-015535-00) – GABA_A receptor positive allosteric modulator
• Zuranolone (SAGE-217) – GABA_A receptor positive allosteric modulator

Orexin receptor antagonists

• Seltorexant (MIN-202, JNJ,42847922, JNJ-922) – selective OX₂ receptor antagonist
• Vornorexant (ORN-0829, TS-142) – dual OX₁ and OX₂ receptor antagonist

Melatonin receptor agonists

• Piromelatine (Neu-P11) – melatonin receptor agonist and 5-HT_1A and 5-HT_1D receptor agonist

Nociceptin receptor agonists

• Sunobinop (IMB-115, IT-1315, S-117957, V-117957) – nociceptin receptor agonist

Narcolepsy

Orexin receptor agonists

• Alixorexton – selective OX₂ receptor agonist^[1]
• Danavorexton (TAK-925) – selective OX₂ receptor agonist via IV infusion^[2]
• E-2086 – selective OX₂ receptor agonist^[3]
• Firazorexton (TAK-994) – OX₂ receptor agonist pill (orally available)^[2]
• Oveporexton (TAK-861) – selective OX₂ receptor agonist (orally available) ^[4]
• Suntinorexton – selective OX₂ receptor agonist (orally available) ^[5]

Monoaminergics

• Flecainide/modafinil (THN-102) – modafinil (dopamine reuptake inhibitor) and flecainide (antiarrhythmic) combination
• Mazindol controlled release (NLS-1001, NLS-1) – norepinephrine-predominant serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI)
• Reboxetine (AXS-12) – norepinephrine reuptake inhibitor (NRI)

GHB receptor agonists

H₃ receptor inverse agonists

• Samelisant (SUVN-G3031) – H₃ receptor antagonist

GABA_A receptor inhibitors

• Pentylenetetrazole (BTD-001) – GABA_A receptor negative allosteric modulator

See also

• List of investigational drugs