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Lophophine
Chemical compound From Wikipedia, the free encyclopedia
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Lophophine, also known as 2C-MMDA-1 or as 3-methoxy-4,5-methylenedioxyphenethylamine (MMDPEA or MMDPEA-1), is a putative psychedelic and entactogen drug of the methylenedioxyphenethylamine family.[1][2] It is the α-demethylated homologue of MMDA, and is also closely related to mescaline (3,4,5-trimethoxyphenethylamine).[1][2]
Alexander Shulgin originally suggested that lophophine may be a natural constituent of peyote (Lophophora williamsii) due to it being the only logical chemical intermediate for the biosynthesis of several tetrahydroisoquinolines known to be present in this cactus species.[1] Subsequently, lophophine was indeed shown to be a minor component of both peyote and San Pedro cactus.[3]
Shulgin reports that lophophine is active in the dose range of 150 to 250 mg.[1][2] He states that at these doses, lophophine has some similarity to mescaline in action, in producing a peaceful elevation of mood, euphoria, and mild enhancement of visual perception, but without the generation of closed-eye mental imagery.[1][2] Shulgin also notes that, in contrast to mescaline, lophophine causes no nausea.[1][2] He estimated that it was about twice the potency of mescaline.[1][2]
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