LysM domain

In molecular biology the LysM domain is a protein domain found in a wide variety of extracellular proteins and receptors. The LysM domain is named after the Lysin Motif which was the original name given to the sequence motif identified in bacterial proteins. The region was originally identified as a C-terminal repeat found in the Enterococcus hirae muramidase.^[1] The LysM domain is found in a wide range of microbial extracellular proteins, where the LysM domain is thought to provide an anchoring to extracellular polysaccharides such as peptidoglycan and chitin. LysM domains are also found in plant receptors, including NFP, the receptor for Nod factor which is necessary for the root nodule symbiosis between legumes and symbiotic bacteria.^[2] The LysM domain is typically between 44 and 65 amino acid residues in length.^[3] The structure of the LysM domain showed that it is composed of a pair of antiparallel beta strands separated by a pair of short alpha helices.^[4]

LysM domain
Identifiers
Symbol	LysM
Pfam	PF01476
InterPro	IPR000644
SMART	LysM
PROSITE	PS51782
SCOP2	1e0g / SCOPe / SUPFAM
CDD	cd00118
Membranome	1306
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

See also

• Nod factor