Top Qs
Timeline
Chat
Perspective

M1G

Chemical compound From Wikipedia, the free encyclopedia

M1G
Remove ads

M1G (pyrimido[1,2-a]purin-10(3H)-one) is a heterocyclic compound which is a by-product of base excision repair (BER) of a specific type of DNA adduct called M1dG. The M1dG adduct in turn is formed by a condensation reaction between guanosine nucleotides in DNA and either malondialdehyde (propanedial) [1] or acrolein.[2] If not repaired, these adducts are mutagenic and carcinogenic.

Quick Facts Names, Identifiers ...

Malondialdehyde is an end product of lipid peroxidation[2] while acrolein is a result of DNA peroxidation.[3]

M1dG is the major endogenous DNA adduct in humans. M1dG adducts have been detected in cell DNA in liver, leucocytes, pancreas and breast in concentrations of 1-120 per 108 nucleotides.[1] Detection and quantification of M1dG adducts in the body as measured by free M1G is a tool for detecting DNA damage that may lead to cancer. Free M1G is also biomarker for oxidative stress.[1]

Remove ads

References

Loading related searches...

Wikiwand - on

Seamless Wikipedia browsing. On steroids.

Remove ads