7-Methylguanosine

7-Methylguanosine (m⁷G) is a modified purine nucleoside. It is a methylated version of guanosine and when found in human urine, it may be a biomarker of some types of cancer. In the RNAs, 7-methylguanosine have been used to study and examine the reaction evolving methylguanosine. It also participates in the formation of 5'-cap that stabilizes mRNA and prevents its degradation by 5' exonucleases.^[1][2]

7-Methylguanosine

Names
IUPAC name 7-Methylguanosin-7-ium
Systematic IUPAC name 2-Amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-methyl-6-oxo-6,9-dihydro-1H-purin-7-ium
Other names N7-Methylguanosine; 2-Amino-1,6-dihydro-7-methyl-6-oxo-9-β-D-ribofuranosylpurinium
Identifiers
CAS Number	20244-86-4 Y
3D model (JSmol)	Interactive image
Abbreviations	m7G; m7G
ChEBI	CHEBI:20794 Y
ChemSpider	393054 Y
PubChem CID	445404
UNII	5290OM2I6G Y
InChI InChI=1S/C11H15N5O5/c1-15-3-16(8-5(15)9(20)14-11(12)13-8)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2-,12,13,14,20)/p+1/t4-,6-,7-,10-/m1/s1 Y Key: OGHAROSJZRTIOK-KQYNXXCUSA-O Y InChI=1/C11H15N5O5/c1-15-3-16(8-5(15)9(20)14-11(12)13-8)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2-,12,13,14,20)/p+1/t4-,6-,7-,10-/m1/s1 Key: OGHAROSJZRTIOK-UJMNIJGGBX
SMILES O=C3/N=C(/N)Nc1c3n(c[n+]1[C@@H]2O[C@@H]([C@@H](O)[C@H]2O)CO)C
Properties
Chemical formula	C11H16N5O5
Molar mass	298.279 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

See also

• m7G(5')pppN diphosphatase
• METTL1
• Messenger RNA decapping
• 23S rRNA (guanine2445-N2)-methyltransferase
• 16S rRNA (guanine527-N7)-methyltransferase
• N1-Methylguanosine (m¹G)