METTL1

tRNA (guanine-N(7)-)-methyltransferase is an enzyme that in humans is encoded by the METTL1 gene.^[5][6]

METTL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3CKK
Identifiers
Aliases	METTL1, C12orf1, TRM8, TRMT8, YDL201w, methyltransferase like 1, methyltransferase 1, tRNA methylguanosine
External IDs	OMIM: 604466; MGI: 1339986; HomoloGene: 3918; GeneCards: METTL1; OMA:METTL1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q14.1 Start 57,768,471 bp[1] End 57,772,119 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D3 Start 127,041,414 bp[2] End 127,046,365 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas gonad pancreatic ductal cell left adrenal cortex right adrenal gland testicle right lobe of thyroid gland right adrenal cortex stromal cell of endometrium left lobe of thyroid gland Top expressed in lacrimal gland yolk sac epiblast embryo blastocyst embryo right kidney morula proximal tubule primitive streak More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methyltransferase activity transferase activity tRNA binding tRNA (guanine-N7-)-methyltransferase activity protein binding RNA binding Cellular component tRNA methyltransferase complex nucleolus nucleus nucleoplasm cytosol Biological process methylation tRNA modification tRNA processing tRNA (guanine-N7)-methylation tRNA methylation RNA (guanine-N7)-methylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4234 17299 Ensembl ENSG00000037897 ENSMUSG00000006732 UniProt Q9UBP6 Q9Z120 RefSeq (mRNA) NM_005371 NM_023032 NM_023033 NM_010792 RefSeq (protein) NP_005362 NP_075422 NP_034922 Location (UCSC) Chr 12: 57.77 – 57.77 Mb Chr 10: 127.04 – 127.05 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms and transcript variants utilizing alternative polyA sites have been described in the literature.^[6]

See also

• 7-Methylguanosine