H2AFY2

Core histone macro-H2A.2 is a protein that in humans is encoded by the H2AFY2 gene.^[5][6][7]

MACROH2A2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XD7
Identifiers
Aliases	MACROH2A2, macroH2A2, H2A histone family member Y2, H2AFY2, macroH2A.2 histone
External IDs	OMIM: 616141; MGI: 3037658; HomoloGene: 10246; GeneCards: MACROH2A2; OMA:MACROH2A2 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q22.1 Start 70,052,544 bp[1] End 70,112,282 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B4 Start 61,574,444 bp[2] End 61,619,926 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone epithelium of colon gingival epithelium cerebellar vermis pancreatic epithelial cell islet of Langerhans epithelium of esophagus hair follicle cerebellar hemisphere Top expressed in genital tubercle tail of embryo neural tube ventricular zone maxillary prominence ganglionic eminence mandibular prominence medial ganglionic eminence otic placode abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding protein heterodimerization activity chromatin DNA binding Cellular component ESC/E(Z) complex nucleoplasm chromosome nucleosome chromatin extracellular exosome Barr body nucleus Biological process nucleosome assembly negative regulation of transcription of nucleolar large rRNA by RNA polymerase I positive regulation of keratinocyte differentiation dosage compensation negative regulation of transcription by RNA polymerase II establishment of protein localization to chromatin brain development negative regulation of gene expression, epigenetic regulation of cell growth chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55506 404634 Ensembl ENSG00000099284 ENSMUSG00000020086 UniProt Q9P0M6 Q8CCK0 RefSeq (mRNA) NM_018649 NM_207000 RefSeq (protein) NP_061119 NP_996883 Location (UCSC) Chr 10: 70.05 – 70.11 Mb Chr 10: 61.57 – 61.62 Mb PubMed search [3] [4]
Wikidata
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