Ensconsin

Ensconsin is a protein that in humans is encoded by the MAP7 gene.^[5][6]

MAP7
Identifiers
Aliases	MAP7, E-MAP-115, EMAP115, microtubule associated protein 7
External IDs	OMIM: 604108; MGI: 1328328; HomoloGene: 20851; GeneCards: MAP7; OMA:MAP7 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q23.3 Start 136,342,281 bp[1] End 136,550,819 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 A3|10 9.75 cM Start 20,024,217 bp[2] End 20,157,336 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell inferior ganglion of vagus nerve hair follicle inferior olivary nucleus optic nerve subthalamic nucleus kidney tubule Brodmann area 23 mucosa of sigmoid colon jejunal mucosa Top expressed in neural layer of retina epithelium of lens submandibular gland crypt of lieberkuhn of small intestine retinal pigment epithelium globus pallidus Paneth cell deep cerebellar nuclei left colon pineal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor binding structural molecule activity protein binding Cellular component perinuclear region of cytoplasm plasma membrane basolateral plasma membrane microtubule cytoskeleton membrane microtubule associated complex microtubule cytoskeleton cytoplasm cytosol axon Biological process response to osmotic stress establishment or maintenance of cell polarity protein localization to plasma membrane microtubule cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9053 17761 Ensembl ENSG00000135525 ENSMUSG00000019996 UniProt Q14244 O88735 RefSeq (mRNA) NM_001198608 NM_001198609 NM_001198611 NM_001198614 NM_001198615 NM_001198616 NM_001198617 NM_001198618 NM_001198619 NM_003980 NM_001198635 NM_001198636 NM_008635 NM_001358787 RefSeq (protein) NP_001185537 NP_001185538 NP_001185540 NP_001185543 NP_001185544 NP_001185545 NP_001185546 NP_001185547 NP_001185548 NP_003971 NP_001185564 NP_032661 NP_001345716 Location (UCSC) Chr 6: 136.34 – 136.55 Mb Chr 10: 20.02 – 20.16 Mb PubMed search [3] [4]
Wikidata
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Function

The product of this gene is a microtubule-associated protein that is predominantly expressed in cells of epithelial origin. Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is essential for cell polarization and differentiation. This protein has been shown to be able to stabilize microtubules, and may serve to modulate microtubule functions. Studies of the related mouse protein also suggested an essential role in microtubule function required for spermatogenesis.^[6]

In addition, MAPs also play a role in regulating cellular transport. MAP7 is a necessary cofactor to activate and subsequently transport cargos by Kinesin-1. ^{[7] [8]}

MAP7's effect on Dynein is still debated.^{[9] [10]}

Interactions

MAP7 has been shown to interact with TRPV4.^[11]