Megakaryocyte-associated tyrosine kinase

For the plant gene, see maturase K.

Megakaryocyte-associated tyrosine-protein kinase is an enzyme that in humans is encoded by the MATK gene.^[5][6][7]

MATK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JWO, 1X6G, 3US4
Identifiers
Aliases	MATK, CHK, CTK, HHYLTK, HYL, HYLTK, Lsk, Megakaryocyte-associated tyrosine kinase
External IDs	OMIM: 600038; MGI: 99259; HomoloGene: 48104; GeneCards: MATK; OMA:MATK - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 3,777,970 bp[1] End 3,802,129 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 39.72 cM|10 C1 Start 81,088,769 bp[2] End 81,099,199 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte cingulate gyrus anterior cingulate cortex right frontal lobe Brodmann area 9 amygdala prefrontal cortex nucleus accumbens putamen caudate nucleus Top expressed in superior frontal gyrus primary visual cortex dentate gyrus of hippocampal formation granule cell lumbar subsegment of spinal cord entorhinal cortex perirhinal cortex hippocampus proper olfactory tubercle subiculum lateral septal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity non-membrane spanning protein tyrosine kinase activity kinase activity protein binding protein tyrosine kinase activity signaling receptor binding ATP binding Cellular component cytoplasm cytosol membrane extrinsic component of cytoplasmic side of plasma membrane Biological process cell differentiation phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway protein phosphorylation positive regulation of cell population proliferation peptidyl-tyrosine autophosphorylation mesoderm development cell population proliferation innate immune response ERBB2 signaling pathway peptidyl-tyrosine phosphorylation regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4145 17179 Ensembl ENSG00000007264 ENSMUSG00000004933 UniProt P42679 P41242 RefSeq (mRNA) NM_002378 NM_139354 NM_139355 NM_001285853 NM_001285854 NM_001285855 NM_010768 RefSeq (protein) NP_002369 NP_647611 NP_647612 NP_001272782 NP_001272783 NP_001272784 NP_034898 Location (UCSC) Chr 19: 3.78 – 3.8 Mb Chr 10: 81.09 – 81.1 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene.^[7]

Interactions

Megakaryocyte-associated tyrosine kinase has been shown to interact with CD117^[8][9] and TrkA.^[10]