Matrilin-2

Matrilin-2 is a matrilin protein that in humans is encoded by the MATN2 gene.^[5][6][7]

MATN2
Identifiers
Aliases	MATN2, matrilin 2
External IDs	OMIM: 602108; MGI: 109613; HomoloGene: 20538; GeneCards: MATN2; OMA:MATN2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q22.1-q22.2 Start 97,868,840 bp[1] End 98,036,724 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 B3.1 Start 34,306,823 bp[2] End 34,436,419 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia trigeminal ganglion spinal ganglia seminal vesicula canal of the cervix Achilles tendon tail of epididymis thyroid gland right ovary left lobe of thyroid gland Top expressed in external carotid artery efferent ductule vas deferens sciatic nerve internal carotid artery seminal vesicula Gonadal ridge tunica adventitia of aorta cervix decidua More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding protein binding molecular function extracellular matrix structural constituent Cellular component extracellular region basement membrane extracellular matrix extracellular space collagen-containing extracellular matrix Biological process glial cell migration dendrite regeneration axon guidance neuron migration response to axon injury neuron projection development biological process growth plate cartilage chondrocyte morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4147 17181 Ensembl ENSG00000132561 ENSMUSG00000022324 UniProt O00339 Q3TQ80 RefSeq (mRNA) NM_002380 NM_030583 NM_001317748 NM_016762 NM_001358780 RefSeq (protein) NP_001304677 NP_002371 NP_085072 NP_058042 NP_001345709 Location (UCSC) Chr 8: 97.87 – 98.04 Mb Chr 15: 34.31 – 34.44 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the von Willebrand factor A domain containing protein family. This family of proteins is thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This protein contains five von Willebrand factor A domains. The specific function of this gene has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene.^[7]