MCHB-1

MCHB-1 is a benzimidazole derived drug which was researched as an analgesic but never developed for medical use. It acts as a potent agonist of the CB₂ receptor, with an EC₅₀ of 0.52nM at CB₂, and ~30x selectivity over CB₁ (Ki of 110nM at CB₁ vs 3.7nM at CB₂).^[1][2] It has been sold online as a designer drug, first being identified in Germany in December 2013.^[3]

MCHB-1

Identifiers
IUPAC name 2-(4-ethoxybenzyl)-1-(cyclohexylmethyl)-N,N-diethyl-1H-benzo[d]imidazole-5-carboxamide
CAS Number	1046140-32-2
PubChem CID	44561533
UNII	W8QNY2T4YC
ChEMBL	ChEMBL470965
CompTox Dashboard (EPA)	DTXSID501336524
Chemical and physical data
Formula	C28H37N3O2
Molar mass	447.623 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCN(CC)C(=O)C1=CC2=C(C=C1)N(C(=N2)CC3=CC=C(C=C3)OCC)CC4CCCCC4
InChI InChI=1S/C28H37N3O2/c1-4-30(5-2)28(32)23-14-17-26-25(19-23)29-27(31(26)20-22-10-8-7-9-11-22)18-21-12-15-24(16-13-21)33-6-3/h12-17,19,22H,4-11,18,20H2,1-3H3 Key:WRVZBXHTUOPQJS-UHFFFAOYSA-N

See also

• AZD1940
• AZ-11713908
• BIM-018
• Etazen
• Etoacetazene