MDGA2

MDGA2 (MAM domain containing glycosylphosphatidylinositol anchor 2) is a human gene. It has previously been called MAMDC1.^[1] MDGA2 is located on chromosome 14.

MAM domain containing glycosylphosphatidylinositol anchor 2
Identifiers
Symbol	MDGA2
Alt. symbols	MAMDC1
NCBI gene	161357
HGNC	19835
OMIM	611128
RefSeq	NM_182830
Other data
Locus	Chr. 14 q21.2

The gene has a homologue in rat and mouse, Mdga2,^[2] and investigations in rats have found that the gene is expressed in the central and peripheral nervous system in a subpopulation of neurons, e.g., in the basilar pons and cerebral cortex.^[3]

There are several variants in the human gene,^[4] and a genome-wide association study has pointed to that single-nucleotide polymorphisms in MDGA2 is associated with neuroticism.^[5] However, a more recent study has failed to replicate that finding.^[6]