MHC class I polypeptide–related sequence B

MHC class I polypeptide-related sequence B (MICB) is a protein that is encoded by the MICB gene located within MHC locus.^[5] MICB is related to MHC class I and has similar domain structure, which is made up of external α1α2α3 domain, transmembrane segment and C-terminal cytoplasmic tail.^[5] MICB is a stress-induced ligand for NKG2D receptor.^[6] The heat shock stress pathway is involved in the regulation of MICB expression as transcription of MICB is regulated by promoter heat shock element.^[7]

MICB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JE6, 2WY3
Identifiers
Aliases	MICB, PERB11.2, MHC class I polypeptide-related sequence B
External IDs	OMIM: 602436; MGI: 2179989; HomoloGene: 88329; GeneCards: MICB; OMA:MICB - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.33 Start 31,494,881 bp[1] End 31,511,124 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A3|7 9.35 cM Start 18,573,891 bp[2] End 18,599,327 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte blood stromal cell of endometrium lymph node bone marrow gonad bone marrow cells spleen appendix Top expressed in urinary bladder uterus lung ovary white adipose tissue adrenal gland zone of skin esophagus muscle tissue skeletal muscle tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function natural killer cell lectin-like receptor binding Cellular component integral component of membrane cell surface plasma membrane membrane extracellular space external side of plasma membrane Biological process immune system process gamma-delta T cell activation viral process response to heat cytolysis adaptive immune response response to oxidative stress response to retinoic acid T cell mediated cytotoxicity natural killer cell mediated cytotoxicity regulation of immune response immune response-activating cell surface receptor signaling pathway immune response natural killer cell activation susceptibility to natural killer cell mediated cytotoxicity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4277 243864 Ensembl ENSG00000231179 ENSG00000224378 ENSG00000206449 ENSG00000227772 ENSG00000238289 ENSG00000231372 ENSG00000234218 ENSG00000204516 ENSMUSG00000040987 UniProt Q29980 Q8HWE5 RefSeq (mRNA) NM_001289160 NM_001289161 NM_005931 NM_153760 NM_153761 RefSeq (protein) NP_001276089 NP_001276090 NP_005922 NP_715641 NP_715642 Location (UCSC) Chr 6: 31.49 – 31.51 Mb Chr 7: 18.57 – 18.6 Mb PubMed search [3] [4]
Wikidata
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See also

• MICA