ML domain

The MD-2-related lipid-recognition (ML) domain is implicated in lipid recognition, particularly in the recognition of pathogen related products. It has an immunoglobulin-like beta-sandwich fold similar to that of immunoglobulin E-set domains. This domain is present in the following proteins:

• Epididymal secretory protein E1 (also known as Niemann-Pick C2 protein), which is known to bind cholesterol. Niemann-Pick disease type C2 is a fatal hereditary disease characterised by accumulation of low-density lipoprotein-derived cholesterol in lysosomes.^[1]
• House dust mite allergen proteins such as Der f 2 from Dermatophagoides farinae and Der p 2 from Dermatophagoides pteronyssinus.^[2]

ML domain
X-ray structure of Der p 2, the major house dust mite allergen
Identifiers
Symbol	E1_DerP2_DerF2
Pfam	PF02221
InterPro	IPR003172
SCOP2	1a9v / SCOPe / SUPFAM
OPM superfamily	91
OPM protein	1nep
CDD	cd00912
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Human proteins containing this domain

LY86; LY96; MMD-1;