MOF-5

MOF-5 or IRMOF-1 is a cubic metal–organic framework compound with the formula Zn₄O(BDC)₃, where BDC²⁻ = 1,4-benzodicarboxylate (MOF-5).^[1] It was first synthesized by graduate students and post doctoral scholars in the lab of Omar M. Yaghi. MOF-5 is notable for exhibiting one of the highest surface area to volume ratios among metal–organic frameworks, at 2200 m²/cm³.^[2] Additionally, it was the first metal–organic framework studied for hydrogen gas storage.^[1][2]

Yaghi's work on MOF-5 is partially responsible for his 2025 Nobel Prize in Chemistry.^[3]