TTK (gene)

Dual specificity protein kinase TTK also known as Mps1 is an enzyme that in humans is encoded by the TTK gene.^[5][6]

TTK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2X9E, 2ZMC, 2ZMD, 3CEK, 3DBQ, 3GFW, 3H9F, 3HMN, 3HMO, 3HMP, 3VQU, 3W1F, 3WYX, 3WYY, 3WZJ, 3WZK, 4B94, 4BHZ, 4BI0, 4BI1, 4BI2, 4C4E, 4C4G, 4C4H, 4C4I, 4C4J, 4CV8, 4CV9, 4CVA, 4D2S, 4H7X, 4H7Y, 4JS8, 4JT3, 4O6L, 5AP0, 5AP1, 5AP2, 5AP3, 5AP4, 5AP5, 5AP6, 5AP7, 5EI2, 5EHY, 5EH0, 5EI6, 4ZEG, 5EI8
Identifiers
Aliases	TTK, CT96, ESK, MPH1, MPS1, MPS1L1, PYT, TTK protein kinase
External IDs	OMIM: 604092; MGI: 1194921; HomoloGene: 2489; GeneCards: TTK; OMA:TTK - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q14.1 Start 80,003,887 bp[1] End 80,042,527 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 E2 Start 83,716,742 bp[2] End 83,754,442 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte ventricular zone gonad testicle ganglionic eminence sperm trabecular bone right testis left testis bone marrow Top expressed in zygote primary oocyte genital tubercle tail of embryo maxillary prominence secondary oocyte mandibular prominence epiblast spermatocyte spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function kinase activity transferase activity protein serine/threonine/tyrosine kinase activity protein serine/threonine kinase activity protein tyrosine kinase activity nucleotide binding protein kinase activity protein binding ATP binding protein homodimerization activity kinetochore binding Cellular component spindle membrane cytoplasm kinetochore nucleus Biological process chromosome separation mitotic spindle organization positive regulation of pathway-restricted SMAD protein phosphorylation spindle organization mitotic spindle assembly checkpoint signaling positive regulation of cell population proliferation protein phosphorylation phosphorylation mitotic cell cycle checkpoint signaling peptidyl-tyrosine phosphorylation female meiosis chromosome segregation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation meiotic spindle assembly checkpoint signaling protein localization to kinetochore protein localization to chromosome protein autophosphorylation protein localization to meiotic spindle midzone chromosome segregation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7272 22137 Ensembl ENSG00000112742 ENSMUSG00000038379 UniProt P33981 P35761 RefSeq (mRNA) NM_001166691 NM_003318 NM_001110265 NM_001284272 NM_009445 RefSeq (protein) NP_001160163 NP_003309 NP_001103735 NP_001271201 NP_033471 Location (UCSC) Chr 6: 80 – 80.04 Mb Chr 9: 83.72 – 83.75 Mb PubMed search [3] [4]
Wikidata
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