Mitochondrial ribosomal protein L1

39S ribosomal protein L1, mitochondrial is a protein that in humans is encoded by the MRPL1 gene.^[5]

MRPL1
Identifiers
Aliases	MRPL1, BM022, L1MT, MRP-L1, mitochondrial ribosomal protein L1
External IDs	OMIM: 611821; MGI: 2137202; HomoloGene: 41355; GeneCards: MRPL1; OMA:MRPL1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q21.1 Start 77,862,830 bp[1] End 77,952,785 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E3 Start 96,357,352 bp[2] End 96,414,586 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in myocardium of left ventricle Skeletal muscle tissue of rectus abdominis Skeletal muscle tissue of biceps brachii deltoid muscle quadriceps femoris muscle vastus lateralis muscle tibialis anterior muscle gonad muscle of thigh mucosa of transverse colon Top expressed in interventricular septum intercostal muscle myocardium of ventricle seminiferous tubule epithelium of small intestine soleus muscle left lobe of liver cumulus cell quadriceps femoris muscle epiblast More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome protein binding RNA binding box H/ACA snoRNA binding Cellular component mitochondrial inner membrane large ribosomal subunit ribosome cytosolic large ribosomal subunit mitochondrion box H/ACA snoRNP complex Biological process mitochondrial translational elongation mitochondrial translational termination maturation of LSU-rRNA protein biosynthesis cleavage involved in rRNA processing rRNA pseudouridine synthesis snRNA pseudouridine synthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 65008 94061 Ensembl ENSG00000169288 ENSMUSG00000029486 UniProt Q9BYD6 Q99N96 RefSeq (mRNA) NM_020236 NM_001039084 NM_053158 RefSeq (protein) NP_064621 NP_001034173 NP_444388 Location (UCSC) Chr 4: 77.86 – 77.95 Mb Chr 5: 96.36 – 96.41 Mb PubMed search [3] [4]
Wikidata
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Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L1 ribosomal protein family.^[5]