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MS-377

Sigma-1 receptor antagonist From Wikipedia, the free encyclopedia

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MS-377 is a selective antagonist of the sigma-1 receptor.[3] It possesses anti-psychotic properties.

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Properties

MS-377 acts selectively at the sigma-1 receptor as an antagonist. It does not act on dopamine or serotonin receptors unlike most anti-psychotics. Tests have shown that MS-377 could displace ligand binding from the sigma-1 receptor, but did this not happen at the sigma-2, 5-HT2 and D2 receptors, suggesting that it is selective for the sigma-1 receptor.[4]

Despite not acting at serotonin and dopamine receptors, it still affects those monoamine systems. It has been shown that MS-377 reduced the release of serotonin and dopamine induced by PCP.[5] It has also been shown to decrease methamphetamine behavioral sensitization,[6] this is also observed with other sigma antagonists.[7]

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References

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