Metallothionein 2A

Metallothionein-2 is a metallothionein protein that in humans is encoded by the MT2A gene.^[3][4]

MT2A
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1MHU, 2MHU
Identifiers
Aliases	MT2A, MT2, Metallothionein 2A, MT-II, MT-2
External IDs	OMIM: 156360; HomoloGene: 136536; GeneCards: MT2A; OMA:MT2A - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q13 Start 56,608,584 bp[1] End 56,609,497 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pericardium right lobe of liver olfactory bulb mucosa of transverse colon left uterine tube external globus pallidus cartilage tissue right lobe of thyroid gland upper lobe of left lung Region I of hippocampus proper n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding zinc ion binding Cellular component cytoplasm perinuclear region of cytoplasm cytosol nucleus Biological process response to metal ion cellular response to interleukin-3 cellular response to erythropoietin negative regulation of growth cellular response to zinc ion interferon-gamma-mediated signaling pathway cellular copper ion homeostasis cellular zinc ion homeostasis detoxification of copper ion cellular response to cadmium ion cellular response to copper ion nitric oxide mediated signal transduction response to bacterium Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4502 n/a Ensembl ENSG00000125148 n/a UniProt P02795 n/a RefSeq (mRNA) NM_005953 n/a RefSeq (protein) NP_005944 n/a Location (UCSC) Chr 16: 56.61 – 56.61 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

The single-nucleotide polymorphism rs28366003 which substitutes guanine for adenine in MT2A is associated with certain cancers and some chronic diseases.^[5]

Interactions

Metallothionein 2A has been shown to interact with protein kinase D1.^[6]