Metallothionein-3

Metallothionein-3 (also known as Growth Inhibitory Factor) is a protein that in humans is encoded by the MT3 gene.^[5][6][7] It is a 68-amino acid peptide (20 of which are cysteine) that is abnormally under-expressed in the brains of patients with Alzheimer's disease.^[8] Metallothionein-3 is a member of the metallothionein family of proteins.

MT3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2F5H, 2FJ4, 2FJ5
Identifiers
Aliases	MT3, GIF, GIFB, GRIF, Znmetallothionein 3
External IDs	OMIM: 139255; MGI: 97173; HomoloGene: 136800; GeneCards: MT3; OMA:MT3 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q13 Start 56,589,074 bp[1] End 56,591,088 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 C5|8 46.29 cM Start 94,879,235 bp[2] End 94,880,774 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nucleus accumbens putamen Brodmann area 9 temporal lobe amygdala substantia nigra caudate nucleus right frontal lobe prefrontal cortex hippocampus proper Top expressed in choroid plexus of fourth ventricle dentate gyrus of hippocampal formation granule cell perirhinal cortex entorhinal cortex CA3 field primary visual cortex superior frontal gyrus dorsomedial hypothalamic nucleus superior colliculus central gray substance of midbrain More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding protein kinase activator activity metal ion binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process antioxidant activity protein binding copper ion binding cadmium ion binding Cellular component cytoplasm cytosol rough endoplasmic reticulum ribosome astrocyte end-foot postsynaptic density synaptic vesicle plasma membrane dendritic spine astrocyte projection intracellular anatomical structure mitochondrial outer membrane axon inclusion body perinuclear region of cytoplasm microtubule extracellular space nucleus Biological process negative regulation of neuron apoptotic process positive regulation of necrotic cell death cellular lipid catabolic process positive regulation of vascular endothelial growth factor receptor signaling pathway activation of protein kinase B activity negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of protein phosphorylation positive regulation of cell death response to hypoxia zinc ion homeostasis protein kinase B signaling histone modification leptin-mediated signaling pathway removal of superoxide radicals astrocyte development ERK1 and ERK2 cascade negative regulation of neurogenesis regulation of response to food protein stabilization zinc ion transport response to metal ion negative regulation of apoptotic process positive regulation of catalytic activity cholesterol catabolic process cellular response to cadmium ion cellular metal ion homeostasis cadmium ion homeostasis response to oxidative stress negative regulation of hydrogen peroxide catabolic process negative regulation of cysteine-type endopeptidase activity positive regulation of transcription, DNA-templated brain development positive regulation of gene expression positive regulation of lysosomal membrane permeability cellular zinc ion homeostasis negative regulation of cell growth positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress negative regulation of oxidoreductase activity regulation of protein glycosylation positive regulation of ERK1 and ERK2 cascade positive regulation of oxygen metabolic process cellular response to oxidative stress cellular response to nitric oxide negative regulation of reactive oxygen species metabolic process energy reserve metabolic process cell population proliferation negative regulation of autophagy negative regulation of transcription, DNA-templated negative regulation of axon extension negative regulation of necrotic cell death cellular response to hypoxia negative regulation of neuron death apoptotic process detoxification of copper ion cellular response to copper ion cellular response to zinc ion negative regulation of neuron projection development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4504 17751 Ensembl ENSG00000087250 ENSMUSG00000031760 UniProt P25713 P28184 RefSeq (mRNA) NM_005954 NM_013603 RefSeq (protein) NP_005945 NP_038631 Location (UCSC) Chr 16: 56.59 – 56.59 Mb Chr 8: 94.88 – 94.88 Mb PubMed search [3] [4]
Wikidata
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