Mucin 17

Mucin-17 is a protein that in humans is encoded by the MUC17 gene.^[3][4]

MUC17
Identifiers
Aliases	MUC17, MUC3, MUC-17, MUC-3, mucin 17, cell surface associated
External IDs	OMIM: 608424; HomoloGene: 134646; GeneCards: MUC17; OMA:MUC17 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.1 Start 101,020,072 bp[1] End 101,058,859 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in duodenum rectum testicle transverse colon right lobe of liver smooth muscle tissue appendix sural nerve islet of Langerhans right lung n/a More reference expression data BioGPS n/a
Gene ontology Molecular function PDZ domain binding extracellular matrix constituent, lubricant activity protein binding Cellular component Golgi lumen integral component of membrane extracellular region membrane external side of plasma membrane apical plasma membrane plasma membrane collagen-containing extracellular matrix Biological process cellular homeostasis O-glycan processing stimulatory C-type lectin receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 140453 n/a Ensembl ENSG00000169876 n/a UniProt Q685J3 n/a RefSeq (mRNA) NM_001004430 NM_001040105 n/a RefSeq (protein) NP_001035194 n/a Location (UCSC) Chr 7: 101.02 – 101.06 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Membrane mucins, such as MUC17, function in epithelial cells to provide cytoprotection, maintain luminal structure, provide signal transduction, and confer antiadhesive properties upon cancer cells that lose their apical/basal polarization.[supplied by OMIM]^[4]