Mucin 5B

Mucin-5B (MUC-5B) is a protein that in humans is encoded by the MUC5B gene ^[5][6][7][8] and by the Muc5b gene in the mouse. It is one of the five gel-forming mucins. MUC-5B can be found in whole saliva, normal lung mucus, and cervical mucus. In some diseases, such as COPD, chronic rhinosinusitis (CRS), and H. pylori-associated gastric disease, the gene has been found to be upregulated, and this may be related to the pathogenesis of these conditions.^[9]

MUC5B
Identifiers
Aliases	MUC5B, MG1, MUC-5B, MUC5, MUC9, mucin 5B, oligomeric mucus/gel-forming
External IDs	OMIM: 600770; MGI: 1921430; HomoloGene: 136756; GeneCards: MUC5B; OMA:MUC5B - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.5 Start 1,223,066 bp[1] End 1,262,172 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F5|7 87.29 cM Start 141,392,807 bp[2] End 141,426,821 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trachea gallbladder mucosa of transverse colon olfactory zone of nasal mucosa bronchus epithelium of bronchus bronchial epithelial cell tendon of biceps brachii minor salivary glands mucosa of sigmoid colon Top expressed in trachea olfactory epithelium right lung cervix right lung lobe conjunctival fornix cochlea carotid body left lung zygote More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component Golgi lumen extracellular region extracellular exosome intracellular membrane-bounded organelle plasma membrane extracellular space Biological process O-glycan processing stimulatory C-type lectin receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 727897 74180 Ensembl ENSG00000117983 ENSMUSG00000066108 UniProt Q9HC84 n/a RefSeq (mRNA) NM_002458 NM_028801 RefSeq (protein) NP_002449 n/a Location (UCSC) Chr 11: 1.22 – 1.26 Mb Chr 7: 141.39 – 141.43 Mb PubMed search [3] [4]
Wikidata
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Synthesis

All mucins are synthesized in secretory cells known as goblet cells or mucous cells, depending on the tissue location. Their creation, while still not completely understood, begins in the endoplasmic reticulum. From there, the Golgi apparatus builds the O-linked glycans found in mucins. Finally, they are packaged into secretory granules.^[10]