MYLK4

Myosin light chain kinase 4 also known as MYLK4 is an enzyme which in humans is encoded by the MYLK2 gene.^[2] MYLK4 is a member of the myosin light-chain kinase family of serine/threonine-specific protein kinases that phosphorylate the regulatory light chain of myosin II.^[3]

Myosin light chain kinase family, member 4
The crystal structure of the human myosin light chain kinase Loc340156.[1]
Identifiers
Symbol	MYLK4
NCBI gene	340156
HGNC	27972
RefSeq	NM_001012418
UniProt	Q86YV6
Other data
EC number	2.7.11.18
Locus	Chr. 6 p25.2
Search for Structures Swiss-model Domains InterPro

This protein acts as an enzyme that catalyzes the following reaction: ATP + a protein -> ADP + a phosphoprotein.^[4]

MYLK4 is also involved in protein amino acid phosphorylation meaning that it adds a phosphate group onto the molecule.^[5]

Not very much is known about the specific functional characteristics of MLYK4, but it has recently been found that the gene may possibly have a role in having at least one driver mutation for cancer.^[6] MYLK4 may also be involved in transferase activity, ATP binding, protein serine/threonine kinase activity, and also nucleotide binding.^[7] Other names for MYLK4 are CaMLCK like; EG238564; MYLK4; Mylk4; Myosin light chain kinase family, member 4; SgK085; SGK085; Sgk085; Sugen kinase 85; Uncharacterized serine/threonine-protein kinase SgK085.^[8]

There are other known myosin light-chain kinase enzymes.