Unconventional myosin-Ia

Unconventional myosin-Ia is a protein that in humans is encoded by the MYO1A gene.^[5][6][7]

MYO1A
Identifiers
Aliases	MYO1A, BBMI, DFNA48, MIHC, MYHL, myosin IA
External IDs	OMIM: 601478; MGI: 107732; HomoloGene: 21113; GeneCards: MYO1A; OMA:MYO1A - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.3 Start 57,028,517 bp[1] End 57,051,198 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 D3|10 74.62 cM Start 127,541,039 bp[2] End 127,556,809 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa mucosa of transverse colon mucosa of ileum rectum duodenum mucosa of sigmoid colon epithelium of colon C1 segment body of stomach testicle Top expressed in jejunum duodenum colon ileum left colon epithelium of small intestine epithelium of stomach lumbar spinal ganglion Paneth cell spermatocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding actin binding actin filament binding cytoskeletal motor activity calmodulin binding ATP binding microtubule motor activity microtubule binding Cellular component filamentous actin brush border cytoplasm cortical actin cytoskeleton microvillus apical plasma membrane basal plasma membrane plasma membrane raft myosin complex basolateral plasma membrane lateral plasma membrane Biological process hearing microvillus assembly cell projection organization vesicle localization microtubule-based movement Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4640 432516 Ensembl ENSG00000166866 ENSMUSG00000025401 UniProt Q9UBC5 O88329 RefSeq (mRNA) NM_001256041 NM_005379 NM_001081219 RefSeq (protein) NP_001242970 NP_005370 NP_001074688 Location (UCSC) Chr 12: 57.03 – 57.05 Mb Chr 10: 127.54 – 127.56 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene belongs to the myosin superfamily. Myosins are molecular motors that, upon interaction with actin filaments, utilize energy from ATP hydrolysis to generate mechanical force. Each myosin has a conserved N-terminal motor domain that contains both ATP-binding and actin-binding sequences. Following the motor domain is a light-chain-binding 'neck' region containing 1-6 copies of a repeat element, the IQ motif, that serves as a binding site for calmodulin or other members of the EF-hand superfamily of calcium-binding proteins. At the C-terminus, each myosin class has a distinct tail domain that serves in dimerization, membrane binding, protein binding, and/or enzymatic activities and targets each myosin to its particular subcellular location. The myosin-Ia protein is expressed by enterocytes, the epithelial cells that line the luminal surface of the small intestine. In these cells the myosin-1a protein localizes specifically to the brush border. Experiments indicate that the brush border population of the encoded protein turns over rapidly, while its head and tail domains interact transiently with the core actin and plasma membrane, respectively. A rapidly exchanging pool of the unconventional myosin-Ia protein binds to the actin core bundle, which turns over on a much slower timescale.^[8]