KAT6B

This article is about the human gene also known as MYST4. For the computer game, see Myst IV.

K(lysine) acetyltransferase 6B (KAT6B) is an enzyme that in humans is encoded by the KAT6B gene.^[5][6][7]

KAT6B
Identifiers
Aliases	KAT6B, GTPTS, MORF, MOZ2, MYST4, ZC2HC6B, qkf, querkopf, lysine acetyltransferase 6B
External IDs	OMIM: 605880; MGI: 1858746; HomoloGene: 49310; GeneCards: KAT6B; OMA:KAT6B - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q22.2 Start 74,824,927 bp[1] End 75,032,624 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 A3 Start 21,531,502 bp[2] End 21,722,546 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone sural nerve bone marrow cells corpus callosum ganglionic eminence testicle epithelium of colon skeletal muscle tissue stromal cell of endometrium tonsil Top expressed in zygote ventricular zone genital tubercle tail of embryo blastocyst neural layer of retina morula superior frontal gyrus dentate gyrus of hippocampal formation granule cell spermatocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity DNA binding transcription factor binding metal ion binding histone acetyltransferase activity protein binding acetyltransferase activity acyltransferase activity protein-containing complex binding H4 histone acetyltransferase activity histone binding Cellular component nucleoplasm nucleosome MOZ/MORF histone acetyltransferase complex nucleus histone acetyltransferase complex Biological process nucleosome assembly regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of transcription, DNA-templated histone acetylation histone H3 acetylation negative regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II cellular response to leukemia inhibitory factor chromatin organization histone H4 acetylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23522 54169 Ensembl ENSG00000156650 ENSG00000281813 ENSMUSG00000021767 UniProt Q8WYB5 Q8BRB7 RefSeq (mRNA) NM_001256468 NM_001256469 NM_012330 NM_001205241 NM_017479 RefSeq (protein) NP_001243397 NP_001243398 NP_036462 NP_001192170 NP_059507 Location (UCSC) Chr 10: 74.82 – 75.03 Mb Chr 14: 21.53 – 21.72 Mb PubMed search [3] [4]
Wikidata
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Interactions

KAT6B has been shown to interact with RUNX2.^[8]

Clinical significance

It has been demonstrated that de novo mutations in the gene KAT6B causes Young–Simpson syndrome and genitopatellar syndrome.^{[9][10][11][12][13]}