Macrophage elastase

Macrophage elastase (EC 3.4.24.65, metalloelastase, human macrophage metalloelastase (HME), MMP-12) is an enzyme.^[1][2][3][4] This enzyme catalyses the following chemical reaction

Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at -Ala¹⁴-Leu- and -Tyr¹⁶-Leu- in the B chain of insulin

Macrophage elastase
Identifiers
EC no.	3.4.24.65
CAS no.	2594837
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

This enzyme belongs to the peptidase family M10.

See also

• Matrix metallopeptidase 12