MAF (gene)

Transcription factor Maf, also known as proto-oncogene c-Maf or V-maf musculoaponeurotic fibrosarcoma oncogene homolog, is a transcription factor that in humans is encoded by the MAF gene.^[5][6]

MAF
Identifiers
Aliases	MAF, CCA4, c-AYGRP, CTRCT21, MAF bZIP transcription factor
External IDs	OMIM: 177075; MGI: 96909; HomoloGene: 74552; GeneCards: MAF; OMA:MAF - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q23.2 Start 79,585,843 bp[1] End 79,600,737 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 E1|8 62.61 cM Start 116,409,681 bp[2] End 116,434,533 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa germinal epithelium gums gingival epithelium trigeminal ganglion skin of hip parietal pleura human penis periodontal fiber vulva Top expressed in stroma of bone marrow skin of external ear molar umbilical cord epithelium of lens left lung lobe body of femur migratory enteric neural crest cell mesenteric lymph nodes human fetus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding protein binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component cytoplasm chromatin nucleus Biological process inner ear development cytokine production regulation of chondrocyte differentiation positive regulation of gene expression lens development in camera-type eye lens fiber cell differentiation negative regulation of transcription by RNA polymerase II regulation of transcription, DNA-templated cell development transcription, DNA-templated positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4094 17132 Ensembl ENSG00000178573 ENSMUSG00000055435 UniProt O75444 P54843 RefSeq (mRNA) NM_001031804 NM_005360 NM_001025577 RefSeq (protein) NP_001026974 NP_005351 NP_001020748 Location (UCSC) Chr 16: 79.59 – 79.6 Mb Chr 8: 116.41 – 116.43 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Types

One type, MafA, also known as RIPE3b1,^[7] promotes pancreatic development, as well as insulin gene transcription.^[8]

Interactions

MAF has been shown to interact with:

• CREBBP^[9]
• EP300^[9]
• MYB^[10]
• SOX9.^[11]