Mafenide

Mafenide (INN; usually as mafenide acetate, trade name Sulfamylon) is a sulfonamide-type medication used as an antibiotic. It was approved by the FDA in 1948.^{[citation needed]}

Mafenide

Clinical data
Trade names	Sulfamylon, Mafylon
AHFS/Drugs.com	Monograph
Routes of administration	Topical
ATC code	D06BA03 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name 4-(Aminomethyl)benzenesulfonamide
CAS Number	138-39-6 N
PubChem CID	3998
DrugBank	DB06795 Y
ChemSpider	3858 Y
UNII	58447S8P4L
KEGG	D02351 Y
ChEMBL	ChEMBL419 Y
CompTox Dashboard (EPA)	DTXSID6047860
ECHA InfoCard	100.004.843
Chemical and physical data
Formula	C7H10N2O2S
Molar mass	186.23 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=S(=O)(c1ccc(cc1)CN)N
InChI InChI=1S/C7H10N2O2S/c8-5-6-1-3-7(4-2-6)12(9,10)11/h1-4H,5,8H2,(H2,9,10,11) Y Key:TYMRLRRVMHJFTF-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Uses

Mafenide is used to treat severe burns.^[1][2] It is used topically as an adjunctive therapy for second- and third-degree burns. It is bacteriostatic against many gram-positive and gram-negative organisms, including Pseudomonas aeruginosa. Some sources state that mafenide is more appropriate for non-facial burns, while chloramphenicol/prednisolone or bacitracin are more appropriate for facial burns.^[3]

Mechanism of action

Mafenide works by reducing the bacterial population present in the avascular tissues of burns and permits spontaneous healing of deep partial-thickness burns. ^{[citation needed]}

Adverse reactions

Adverse reactions can include superinfection, pain or burning upon application, rash, pruritus, tachypnea, or hyperventilation. Mafenide is metabolized to a carbonic anhydrase inhibitor, which could potentially result in metabolic acidosis.^[4]

Drug interactions

There are no significant interactions.^{[citation needed]}

Contraindications

Mafenide is contraindicated in those with sulfonamide hypersensitivity or renal impairment.

Dosage

For use as adjunctive therapy for second- and third-degree burns to prevent infection, adults and children should apply topically to a thickness of approximately 1.6 mm to cleaned and debrided wound once or twice per day with a sterile gloved hand. The burned area should be covered with cream at all times.^{[citation needed]}