Major histocompatibility complex, class II, DP alpha 1

Major histocompatibility complex, class II, DP alpha 1, also known as HLA-DPA1, is a human gene.^[1]

Major histocompatibility complex, class II, DP alpha 1
Identifiers
Aliases
External IDs	GeneCards: ; OMA:- orthologs
Orthologs Species Human Mouse Entrez n/a n/a Ensembl n/a n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) n/a n/a PubMed search n/a n/a
Wikidata
View/Edit Human

major histocompatibility complex, class II, DP alpha 1
Identifiers
Symbol	HLA-DPA1
Alt. symbols	HLA-DP1A
NCBI gene	3113
HGNC	4938
OMIM	142880
RefSeq	NM_033554
UniProt	P20036
Other data
Locus	Chr. 6 p21.3
Search for Structures Swiss-model Domains InterPro

Function

The protein encoded by this gene belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen-presenting cells (APC: B lymphocytes, dendritic cells, macrophages).^[1]

Gene structure and polymorphisms

The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons, exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.^[1]

See also

• Major histocompatibility complex
• Human leukocyte antigen
• HLA-DP