Malaprade reaction

In organic chemistry, the Malaprade reaction or Malaprade oxidation is a reaction that converts vicinal diols by periodic acid or a periodate salt to give a pair of carbonyl derivatives.^[1][2] The reaction was first reported by Léon Malaprade in 1928.^[3][4] Amino alcohols are also cleaved.^[5]

In terms of mechanism, the reaction is assumed to proceed by formation of cyclic diester of iodine(VII).^[6]

See also

• Criegee oxidation