Malate dehydrogenase (NADP+)

In enzymology, a malate dehydrogenase (NADP⁺) (EC 1.1.1.82) is an enzyme that catalyzes the chemical reaction

(S)-malate + NADP⁺ ${\displaystyle \rightleftharpoons }$ oxaloacetate + NADPH + H⁺

malate dehydrogenase (NADP+)
Malate dehydrogenase (NADP+) homodimer, Flaveria bidentis
Identifiers
EC no.	1.1.1.82
CAS no.	37250-19-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are (S)-malate and NADP⁺, whereas its 3 products are oxaloacetate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (S)-malate:NADP⁺ oxidoreductase. Other names in common use include NADP⁺-malic enzyme, NADP⁺-malate dehydrogenase, malic dehydrogenase (nicotinamide adenine dinucleotide phosphate), malate NADP⁺ dehydrogenase, NADP⁺ malate dehydrogenase, NADP⁺-linked malate dehydrogenase, and malate dehydrogenase (NADP⁺). This enzyme participates in pyruvate metabolism and carbon fixation. This enzyme has at least one effector, hn.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1CIV and 7MDH.