Β-Mannosidase

For other uses of "MANBA", see Manba (disambiguation).

β-Mannosidase (EC 3.2.1.25}, mannanase, mannase, β-D-mannosidase, β-mannoside mannohydrolase, exo-β-D-mannanase, lysosomal β A mannosidase) is an enzyme with systematic name β-D-mannoside mannohydrolase, which is in humans encoded by the MANBA gene.^{[5][6][7][8][9][10]} This enzyme catalyses the following chemical reaction

Hydrolysis of terminal, non-reducing β-D-mannose residues in β-D-mannosides

MANBA
Identifiers
Aliases	MANBA, MANB1, mannosidase beta
External IDs	OMIM: 609489; MGI: 88175; HomoloGene: 4317; GeneCards: MANBA; OMA:MANBA - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q24 Start 102,630,770 bp[1] End 102,760,994 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 G3|3 62.65 cM Start 135,191,372 bp[2] End 135,277,165 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte stromal cell of endometrium granulocyte parotid gland right adrenal cortex tendon of biceps brachii blood Achilles tendon left adrenal gland right lung Top expressed in utricle vestibular sensory epithelium vestibular membrane of cochlear duct right kidney stroma of bone marrow epithelium of small intestine medullary collecting duct human kidney epithelium of stomach saccule More reference expression data BioGPS n/a
Gene ontology Molecular function hydrolase activity hydrolase activity, hydrolyzing O-glycosyl compounds mannose binding hydrolase activity, acting on glycosyl bonds beta-mannosidase activity Cellular component lysosome lysosomal lumen plasma membrane azurophil granule membrane intracellular membrane-bounded organelle Biological process metabolism oligosaccharide catabolic process neutrophil degranulation carbohydrate metabolic process glycoprotein catabolic process mannan catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4126 110173 Ensembl ENSG00000109323 ENSMUSG00000028164 UniProt O00462 Q8K2I4 RefSeq (mRNA) NM_005908 NM_027288 RefSeq (protein) NP_005899 NP_081564 Location (UCSC) Chr 4: 102.63 – 102.76 Mb Chr 3: 135.19 – 135.28 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

β-Mannosidase
Identifiers
EC no.	3.2.1.25
CAS no.	9025-43-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

This gene encodes a member of the glycosyl hydrolase 2 family. The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N-linked glycoprotein oligosaccharide catabolism. Mutations in this gene are associated with β-mannosidosis, a lysosomal storage disease that has a wide spectrum of neurological involvement.^[5]