Mannitol-1-phosphate 5-dehydrogenase

In enzymology, a mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17) is an enzyme that catalyzes the chemical reaction

D-mannitol 1-phosphate

+ NAD⁺

 

 

 

H⁺

 

H⁺

 

fructose 6-phosphate

+ NADH

 

mannitol-1-phosphate 5-dehydrogenase
Identifiers
EC no.	1.1.1.17
CAS no.	9028-24-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The two substrates of this enzyme are D-mannitol 1-phosphate and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are fructose 6-phosphate, reduced NADH and a proton.^[1][2][3][4]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is D-mannitol-1-phosphate:NAD⁺ 2-oxidoreductase. Other names in common use include hexose reductase, mannitol 1-phosphate dehydrogenase, D-mannitol-1-phosphate dehydrogenase, and fructose 6-phosphate reductase. This enzyme participates in fructose and mannose metabolism.

See also

• D-Mannitol