Mannosylfructose-phosphate synthase

Mannosylfructose-phosphate synthase (EC 2.4.1.246, mannosylfructose-6-phosphate synthase, MFPS) is an enzyme with systematic name GDP-mannose:D-fructose-6-phosphate 2-alpha-D-mannosyltransferase.^[1] This enzyme catalyses the following chemical reaction

GDP-mannose + D-fructose 6-phosphate ${\displaystyle \rightleftharpoons }$ GDP + beta-D-fructofuranosyl-alpha-D-mannopyranoside 6F-phosphate

Mannosylfructose-phosphate synthase
Identifiers
EC no.	2.4.1.246
CAS no.	92480-04-1 (not distinguished from EC 2.4.1.167)
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

This enzyme, from the soil proteobacterium and plant pathogen Agrobacterium tumefaciens strain C58, requires Mg²⁺ or Mn²⁺ for activity.