Marneral synthase

Marneral synthase (EC 5.4.99.53) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, marneral-forming).^[1] This enzyme catalyses the following chemical reaction

(3S)-2,3-epoxy-2,3-dihydrosqualene ${\displaystyle \rightleftharpoons }$ marneral

Marneral synthase
Identifiers
EC no.	5.4.99.53
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Marneral is a triterpenoid formed by Grob fragmentation of the A ring of 2,3-epoxy-2,3-dihydrosqualene during cyclization. This aldehyde gains its name from its structural similarity to a class triterpenes commonly found in members of the Iridaceae, originally identified by Dr. Franz-Josef Marner^[1]

This enzyme is a member of a metabolic gene cluster along with two other cytochrome P450s.^[2]